{"id":{"repo_id":"wfu","oai_identifier":"oai:wakespace.lib.wfu.edu:10339/47458"},"canonical_url":"https://search.dev.ndltd.org/etd/wfu/oai:wakespace.lib.wfu.edu:10339/47458","repository":{"repo_id":"wfu","name":"Wake Forest University","base_url":"https://wakespace.lib.wfu.edu/oai/request"},"display":{"title":"Assessment of Myocardial Fibrosis using Cardiovascular Magnetic Resonance Extracellular Volume Mapping in Cancer Patients Treated with Anthracycline-based Chemotherapy Compared with Untreated Cancer Patients and Cancer-free Peers","abstract":"In this thesis, we will evaluate the effect of anthracycline chemotherapy on measures of myocardial injury and fibrosis using quantitative cardiovascular magnetic resonance (CMR) imaging techniques. Anthracycline-based chemotherapy regimens are often an essential component of curative cancer treatments, but are associated with myocardial injury, heart failure, and cardiovascular events. Elevated native T1 and extracellular volume (ECV) assessments indicative of myocardial fibrosis or injury have been observed in adult cancer survivors treated with anthracyclines. It remains undetermined, however, whether these measures are related to the cancer or the treatment for cancer.","abstract_html":"In this thesis, we will evaluate the effect of anthracycline chemotherapy on measures of myocardial injury and fibrosis using quantitative cardiovascular magnetic resonance (CMR) imaging techniques. Anthracycline-based chemotherapy regimens are often an essential component of curative cancer treatments, but are associated with myocardial injury, heart failure, and cardiovascular events. Elevated native T1 and extracellular volume (ECV) assessments indicative of myocardial fibrosis or injury have been observed in adult cancer survivors treated with anthracyclines. It remains undetermined, however, whether these measures are related to the cancer or the treatment for cancer.","abstract_has_math":false,"creators":["Jordan, Jennifer Hawthorne"],"institution":"Wake Forest University","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2014,"date_issued":"2014","date_published":"2014","updated_at":"2026-07-27T22:01:46Z","subjects":["Cardiotoxicity"],"languages":["en"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10339/47458","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Jordan, Jennifer Hawthorne"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2015-01-21T09:35:18Z"]},{"key":"dc:date.issued","label":"Date","values":["2014"]},{"key":"dc:publisher","label":"Institution","values":["Wake Forest University"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Cardiotoxicity"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/10339/47458"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["In this thesis, we will evaluate the effect of anthracycline chemotherapy on measures of myocardial injury and fibrosis using quantitative cardiovascular magnetic resonance (CMR) imaging techniques. Anthracycline-based chemotherapy regimens are often an essential component of curative cancer treatments, but are associated with myocardial injury, heart failure, and cardiovascular events. Elevated native T1 and extracellular volume (ECV) assessments indicative of myocardial fibrosis or injury have been observed in adult cancer survivors treated with anthracyclines. It remains undetermined, however, whether these measures are related to the cancer or the treatment for cancer."]},{"key":"dc:title","label":"Title","values":["Assessment of Myocardial Fibrosis using Cardiovascular Magnetic Resonance Extracellular Volume Mapping in Cancer Patients Treated with Anthracycline-based Chemotherapy Compared with Untreated Cancer Patients and Cancer-free Peers"]}]}],"canonical_facts":{"dc:creator":["Jordan, Jennifer Hawthorne"],"dc:date.accessioned":["2015-01-21T09:35:18Z"],"dc:date.issued":["2014"],"dc:description.abstract":["In this thesis, we will evaluate the effect of anthracycline chemotherapy on measures of myocardial injury and fibrosis using quantitative cardiovascular magnetic resonance (CMR) imaging techniques. Anthracycline-based chemotherapy regimens are often an essential component of curative cancer treatments, but are associated with myocardial injury, heart failure, and cardiovascular events. Elevated native T1 and extracellular volume (ECV) assessments indicative of myocardial fibrosis or injury have been observed in adult cancer survivors treated with anthracyclines. It remains undetermined, however, whether these measures are related to the cancer or the treatment for cancer."],"dc:identifier.uri":["http://hdl.handle.net/10339/47458"],"dc:language.iso":["en"],"dc:publisher":["Wake Forest University"],"dc:subject":["Cardiotoxicity"],"dc:title":["Assessment of Myocardial Fibrosis using Cardiovascular Magnetic Resonance Extracellular Volume Mapping in Cancer Patients Treated with Anthracycline-based Chemotherapy Compared with Untreated Cancer Patients and Cancer-free Peers"],"dc:type":["Thesis"]},"updated_at":"2026-07-27T22:01:46Z"}