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Showing 1 to 18 of 18 for “"anthracyclines"”.
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Optimization of Optical Nanosensor Response for the Detection of Anthracyclines Using a Binary Machine Learning Classifier
… drugs makes dose selection of chemotherapeutic anthracyclines difficult. One potential solution to determining dosing levels of an anthracycline is the development of non-invasive sensors to monitor their pharmacology in vivo. Single-walled carbon nanotubes (SWCNT) have substantial potential for …
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Development of novel extraction and separation methods for the determination of anthracyclines and taxanes simultaneously from biological matrices
… treatment. Despite the fact that a mixture of anthracyclines and taxanes may be administered simultaneously to patients and that accurate measurement of drug levels during chemotherapy is proven to be more beneficial to patients, currently no chromatographic method exists for the measurement of …
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An investigation of some chromatographic and electrophoretic seperations for industrial and clinical applications
… developed for the simultaneous analysis of the anthracyclines, daunombicin, doxorubicin and epirubicin. Ultra-violet (UV), electrochemical (EC) and laser-induced fluorescence (LIF) detection coupled to CE were investigated. Improved detection limits (150-1400 ng ml-') were obtained with LIF …
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Prevention of cancer therapy related cardiotoxicity: A Tayside Pharmaco-Epidemiology study (PROTECT-TAYSIDE study)
… of these drugs. Cytotoxic antibiotics such as anthracyclines and the monoclonal antibody trastuzamab are both commonly used in breast cancer and may cause irreversible cardiotoxicity, though trastuzumab-induced damage can be reversed upon stopping. Various animal studies have shown that …
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Dearomative hydroboration-enabled synthesis of idarubicinone and synthesis of minor cannabinoids and their metabolites
Anthracyclines are archetypal representatives of tetracyclic type II polyketide natural products that are widely used in cancer chemotherapy. Although syntheses of this class of compounds have been extensively explored, all known approaches are based on annulations, relying on the union of properly …
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Assessment of Myocardial Fibrosis using Cardiovascular Magnetic Resonance Extracellular Volume Mapping in Cancer Patients Treated with Anthracycline-based Chemotherapy Compared with Untreated Cancer Patients and Cancer-free Peers
… observed in adult cancer survivors treated with anthracyclines. It remains undetermined, however, whether these measures are related to the cancer or the treatment for cancer.
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Regulatio of actin cytoskeleton by TIS21 vi downregulating reactive oxygen species (ROS) in the doxorubicin-induced premature senescenc
… anticancer drug that belongs to a class of anthracyclines and a commonly used inducer of DNA damage. Here, we show the role of BTG2 in doxorubicin induced senescence in human diploid fibroblast. We observed increase in SA-β-galstaining, change in cellular morphology, an increase in …
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The genetics of anthracycline-induced cardiotoxicity in cancer patients
… clinical records of cancer patients treated with anthracyclines from 2011- 2016 at the Oncology Clinic at GSH were analysed. Clinical co-morbidities such as hypertension, diabetes, pre-existing cardiac disease and smoking as well as type and dose of anthracyclines, cardiac function and patient …
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Assessing Cardiovascular Disease Risk In Women Newly Diagnosed With Breast Cancer
… breast cancer prior to receiving treatment with anthracyclines and/or trastuzumab. Women diagnosed with breast cancer are at risk for developing CVD and may experience increased risk factors related to breast cancer diagnoses and treatments. The specific aim was to determine baseline …
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Further investigation of capillary electrophoresis for pharmaceutical analysis
… of different types of anticancer drugs - anthracyclines and taxanes. The high hydrophobicity of the drugs requires detailed investigation of suitable buffer composition with additives of miscellaneous component and organic phase. The use of these drugs in combination therapy sparked the …
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ΑΝΑΛΥΣΗ ΤΩΝ ΑΛΛΗΛΕΠΙΔΡΑΣΕΩΝ ΑΝΘΡΑΚΥΚΛΙΝΩΝ-ΣΙΔΗΡΟΠΟΡΦΥΡΙΝΩΝ ΣΤΟ ΑΙΜΟΠΟΙΗΤΙΚΟ ΣΥΣΤΗΜΑ
… THEREFORE, THE ABILITY OF HEMIN TO COUNTERACT ANTHRACYCLINES CYTOTOXICITY APPEARS TO BE OF CLINICAL VALUE IN PROTECTING BONE MARROW AND PERHAPS HEART FROM ADR- MYELOSUPPRESSION AND CARDIOTOXICITY, THUS IMPROVING WELL BEING OF PATIENTS UNDERGOING CHEMOTHERAPY TREATMENT.
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An innate immune response to DNA damage in prostate cancer
… assay has been shown to predict response to anthracyclines and platinum agents in breast, oesophageal and ovarian cancer. We hypothesize that there is a DDRD positive subgroup in prostate cancer, which may fail to benefit from taxane agents, which are the current standard of …
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An investigation on role of the ATP-binding cassette B5 (ABCB5) transporter as potential mediator of melanoma resistance to BRAF inhibition
… of known ABCB5 substrates such as taxanes, anthracyclines, camptothecin and etoposide enabled the identification of at least three putative substrate binding sites in ABCB5. The overlap of these three binding sites with validated binding sites for these chemotherapeutic drugs in Pgp1 …
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Clinical Relevance of the Immune Contexture and AXL Kinase in Triple-Negative Breast Cancer
… cells to chemotherapeutic drugs, especially anthracyclines. <br></br><br></br> Overall, our data indicate that TNBC subgroups with different biological and genomic features are characterized by distinct compositions of the immune microenvironment. Our results confirm that the evaluation of …
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Design Synthesis and Evaluation Of Diterpenones As Potent Chemopreventive Agents For Aflatoxin B1 Induced Carcinogenesis In Human Liver Cells
… and antitumor compounds such as mitomycin C and anthracyclines. The goal of this study was to understand the basis of QM bioactivity so that terpene catechols as analogs of natural TPQMs precursors can be designed as effective chemopreventive agents.In order to investigate the oxidation pathway …
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Melatonin's Protection against DNA Damage by the Iron (III)-Adriamycin Complex.
<p>Adriamycin is a first line cancer treatment drug for breast cancer and many soft tissue carcinomas. Adriamycin is a highly effective anti-cancer drug. It has a fused ring system that is planar, hydrophobic and electron rich. These features allow intercalation into DNA which, along with its …
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Type-5 Phosphodiesterase Inhibition in the Prevention of Doxorubicin Cardiomyopathy
Prior studies have demonstrated the effect of diazoxide in protecting against apoptosis via mitochondrial KATP channel opening in vitro. The current investigations are designed to determine if sildenafil, a phosphodiesterase-5 inhibitor and known mitochondrial KATP channel opener, would protect …