Role of Tumor Suppressor DMP1 in the Initiation and Progression of Breast Cancer

Breast cancer is the second most common cause of cancer related death in women. Decades of research have demonstrated complexity and high heterogeneity of this disease. The tumor heterogeneity is a result of many altered genomic, epigenomic, and protein modification states that contribute to a distinctive proliferative advantage. The same deregulations that initiate tumorigenesis of mammary epithelial cells are believed to coerce therapeutic resistance. On the other hand, population-wide screenings have increased diagnosis of women with breast cancers without specificity for the tumors with an aggressive phenotype. Hence, identification of the cancer cell's intrinsic alterations that faithfully predict tumor progression has a potential to significantly improve their clinical management.

Grantor dc:publisher

Wake Forest University

Year dc:date.issued

2014

Author dc:creator

• Maglic, Dejan

• ARF

Language dc:language.iso

en

Handle dc:identifier.uri

http://hdl.handle.net/10339/39244

OAI identifier oai:identifier

oai:wakespace.lib.wfu.edu:10339/39244