{"id":{"repo_id":"wfu","oai_identifier":"oai:wakespace.lib.wfu.edu:10339/39244"},"canonical_url":"https://search.dev.ndltd.org/etd/wfu/oai:wakespace.lib.wfu.edu:10339/39244","repository":{"repo_id":"wfu","name":"Wake Forest University","base_url":"https://wakespace.lib.wfu.edu/oai/request"},"display":{"title":"Role of Tumor Suppressor DMP1 in the Initiation and Progression of Breast Cancer","abstract":"Breast cancer is the second most common cause of cancer related death in women. Decades of research have demonstrated complexity and high heterogeneity of this disease. The tumor heterogeneity is a result of many altered genomic, epigenomic, and protein modification states that contribute to a distinctive proliferative advantage. The same deregulations that initiate tumorigenesis of mammary epithelial cells are believed to coerce therapeutic resistance. On the other hand, population-wide screenings have increased diagnosis of women with breast cancers without specificity for the tumors with an aggressive phenotype. Hence, identification of the cancer cell's intrinsic alterations that faithfully predict tumor progression has a potential to significantly improve their clinical management.","abstract_html":"Breast cancer is the second most common cause of cancer related death in women. Decades of research have demonstrated complexity and high heterogeneity of this disease. The tumor heterogeneity is a result of many altered genomic, epigenomic, and protein modification states that contribute to a distinctive proliferative advantage. The same deregulations that initiate tumorigenesis of mammary epithelial cells are believed to coerce therapeutic resistance. On the other hand, population-wide screenings have increased diagnosis of women with breast cancers without specificity for the tumors with an aggressive phenotype. Hence, identification of the cancer cell's intrinsic alterations that faithfully predict tumor progression has a potential to significantly improve their clinical management.","abstract_has_math":false,"creators":["Maglic, Dejan"],"institution":"Wake Forest University","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2014,"date_issued":"2014","date_published":"2014","updated_at":"2026-07-27T22:01:39Z","subjects":["ARF"],"languages":["en"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10339/39244","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Maglic, Dejan"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2014-07-10T08:35:20Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2015-07-10T08:30:09Z"]},{"key":"dc:date.issued","label":"Date","values":["2014"]},{"key":"dc:publisher","label":"Institution","values":["Wake Forest University"]},{"key":"dc:type","label":"Dc Type","values":["Dissertation"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["ARF"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/10339/39244"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Breast cancer is the second most common cause of cancer related death in women. Decades of research have demonstrated complexity and high heterogeneity of this disease. The tumor heterogeneity is a result of many altered genomic, epigenomic, and protein modification states that contribute to a distinctive proliferative advantage. The same deregulations that initiate tumorigenesis of mammary epithelial cells are believed to coerce therapeutic resistance. On the other hand, population-wide screenings have increased diagnosis of women with breast cancers without specificity for the tumors with an aggressive phenotype. Hence, identification of the cancer cell's intrinsic alterations that faithfully predict tumor progression has a potential to significantly improve their clinical management."]},{"key":"dc:title","label":"Title","values":["Role of Tumor Suppressor DMP1 in the Initiation and Progression of Breast Cancer"]}]}],"canonical_facts":{"dc:creator":["Maglic, Dejan"],"dc:date.accessioned":["2014-07-10T08:35:20Z"],"dc:date.available":["2015-07-10T08:30:09Z"],"dc:date.issued":["2014"],"dc:description.abstract":["Breast cancer is the second most common cause of cancer related death in women. Decades of research have demonstrated complexity and high heterogeneity of this disease. The tumor heterogeneity is a result of many altered genomic, epigenomic, and protein modification states that contribute to a distinctive proliferative advantage. The same deregulations that initiate tumorigenesis of mammary epithelial cells are believed to coerce therapeutic resistance. On the other hand, population-wide screenings have increased diagnosis of women with breast cancers without specificity for the tumors with an aggressive phenotype. Hence, identification of the cancer cell's intrinsic alterations that faithfully predict tumor progression has a potential to significantly improve their clinical management."],"dc:identifier.uri":["http://hdl.handle.net/10339/39244"],"dc:language.iso":["en"],"dc:publisher":["Wake Forest University"],"dc:subject":["ARF"],"dc:title":["Role of Tumor Suppressor DMP1 in the Initiation and Progression of Breast Cancer"],"dc:type":["Dissertation"]},"updated_at":"2026-07-27T22:01:39Z"}