Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 122 for “"ARF"”.
-
Charakterisierung der peroxisomalen ARF-Bindung
… Beginn der vorliegenden Arbeit war bekannt, daß ARF (ADP-Ribosylierungsfaktor) zusammen mit Coatomer an isolierte Peroxisomen der Rattenleber bindet. Darauf aufbauend wurde zunächst gezeigt, daß die ARF-Bindung für Peroxisomen spezifisch ist und von einer Behandlung der Tiere mit …
-
Cooperative Tumor Suppression by ARF and p53
… Two tumor suppressor genes, p53 and Arf, play important roles in protecting cells against numerous biological stresses. In response to oncogenic signals, increased ARF expression leads to the activation of p53, which in turn leads to the cessation of cell division or induction of an …
-
Role of the ARF Tumor Suppressor in Osteoclasts
The ARF tumor suppressor is upregulated upon oncogenic stress. ARF can suppress cell proliferation in both p53-dependent and -independent mechanisms. We have focused on ARF's ability to suppress protein synthesis in a p53-independent manner. Given that protein synthesis and the cell cycle are …
-
The Arf GTPase exchange factor Sec7p interaction network:
… from endosomal compartments or to the different Arf mediated vesicle formation machineries has still to be established. In addition, the role of lipids and the interplay between lipid and protein regulators at the Golgi are largely missing. In the present study, we used several approaches to …
-
The Areal Reduction Factor (ARF) : a multifractal analysis
The Areal Reduction Factor (ARF) [eta] is a key parameter in the design for hydrologic extremes. For a basin of area A, [eta](A, D, 7) is the ratio between the area-average rainfall intensity over a duration D with return period T and the point rainfall intensity for the same D and T. Besides …
-
Generalized arf invariants and reduced power operations in cyclic homology
Contains fulltext : mmubn000001_111552761.pdf (Publisher’s version ) (Open Access)
-
Regulation of the Arf tumor suppressor by E2F transcription factors
… genes required for cellular proliferation. The Arf tumor suppressor is a key regulator of p53, and causes activation of p53-mediated cell cycle arrest or apoptosis in the presence of unrestrained proliferation due to cellular oncogenes. E2F has been predicted to be a regulator of Arf, but the …
-
Regulation of the Tumor Suppressor ARF by TGFβ in Human Cancer Cells
Since its discovery, p14ARF (p19Arf in mice) has been shown to be an important regulator of the cell cycle, carrying out this function through p53-dependent and independent mechanisms. ARF expression has recently been shown by the Skapek lab to be induced by TGFβ in mouse embryonic fibroblast and …
-
Regulatory domains of the Arf GEF Sec7 scaffold autoinhibited and active conformations
… at the TGN is dependent on the small GTPase Arf1 which drives vesicle formation and membrane modification following its activation by the Arf GEF Sec7. A network of inter- and intramolecular interactions of Sec7 gives robust spatiotemporal specificity to the potent Arf GEF. The Sec7 homodimer …
-
Defining the functions of a conserved hydrophobic domain in the ARF tumor suppressor
The INK4A-ARF locus encodes two tumor suppressors; p16 and p19Arf, both of which restrain cell growth by regulating the functions of Retinoblastoma (Rb) and p53 respectively. Throughout development, p19Arf is kept at minimal levels, but under conditions of oncogenic stress, p19Arf expression is …
-
Assessment of Cardiac Function by Acoustic Radiation Force (ARF) Based Methods of Ultrasound Elastography
… function. </p><p>Acoustic radiation force (ARF) based ultrasound elastography techniques were developed in early 2000s and have been used to measure the static stiffness of tissue. These techniques are being used in the clinic for diagnosis of disorders and malignancies in tissues such as …
-
Beteiligung der Phospholipase D an der Regulation der Synthese von Phosphatidylinositol-4,5-bisphosphat durch Arf- und Rho-GTPasen
… and PIP-5-kinase are stimulated by the GTPases Arf1 and RhoA, we investigated in the following, if PLD is involved in the regulation of PIP2 synthesis by these GTPases. Both PLD1- and PLD2-induced PIP2 synthesis was completely blocked by coexpression of catalytically inactive Arf1 T31N. …
-
Temporal logic-based fuzzy decision support system for diagnosis of rheumatic fever and rheumatic heart disease
… and recognition of Acute Rheumatic Fever (ARF) and Rheumatic Heart Disease (RHD) at an early stage by developing/adopting UK’s and NHF’s treatment practices and procedures that would be appropriate for the Nepalese environment and lifestyle. The Application we developed was designed for use …
-
System identification and control of a miniature external mechanical vibration device towards clinical ultrasound shear wave elastography
An acoustic radiation force (ARF) is commonly used to generate shear waves in ultrasound systems for shear wave elastography (SWE). However, ARF requires complex hardware that produces thermal stresses in tissues and electronic components. External mechanical vibration (EMV) is less …
-
THE ROLE OF DMP1 IN HUMAN BREAST CANCER PROGNOSIS AND CYCLIN D1-INDUCED BREAST CANCER
… factor that directly binds and activates the Arf promoter. It is also a bona fide tumor suppressor that is activated by oncogenic Ras and HER2 signalings and in turn stimulates the Arf-p53 tumor suppression pathway. Dmp1 physically interacts with cyclin D1 that is frequently overexpressed in …
-
A study of determinants and prevalence of Rheumatic Heart Disease in Cape Town
… subsequently result in acute rheumatic fever (ARF). In the absence of intervention, repeated bouts of ARF in turn, may result in progression to RHD, particularly in those ARF patients with cardiac involvement. The prevalence of ARF and RHD in developed countries has shown considerable decline …
-
IMPACT OF SARS-COV-2 RESPIRATORY INFECTION ON CLINICAL OUTCOMES AND NEED FOR NON-INVASIVE VENTILATORY SUPPORT IN ACUTE EXACERBATIONS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE: A SINGLE-CENTER, PROSPECTIVE, OBSERVATIONAL STUDY
… identify the risk of acute respiratory failure (ARF) requiring non-invasive respiratory support up to Continuous Positive Airway Pressure (C-PAP) and Non-Invasive Ventilation (NIV) in patients affected by SARS-CoV-2 triggered COPD exacerbation compared to patients with COPD exacerbations without …
-
Novel interactions of the 5-HT₂ₐ and related receptors with intracellular signalling proteins
… D (PLD) pathway in an ADP-ribosylation factor (ARF)-dependent manner, that appears to be independent of Gq/n. The M3 muscarinic receptor, another member of the group I GPCRs, has also been shown to signal through both PLC (via Got) and the alternative pathway of PLD activation via ARF. In this …
-
The augmented reality framework : an approach to the rapid creation of mixed reality environments and testing scenarios
… framework, the Augmented Reality Framework (ARF), for rapid construction of virtual environments for Augmented Reality tasks such as Pure Simulation, HIL, Hybrid Simulation and real world testing. ARF’s architecture is based on JavaBeans and is therefore inherently generic, flexible and …
Page 1 of 7