E1B and E4 adenoviral oncoproteins modulate cellular responses to DNA damage

A productive adenovirus infection inundates the host cell with linear, double-stranded DNA molecules and an abundance of single-stranded DNA. The cellular responses of cell death and cell cycle arrest to this apparent profusion of damaged DNA are antagonized by overlapping activities encoded in the adenoviral E1B and E4 early genes. A mutant group C adenovirus that fails to express the E1B-55K and E4ORF3 genes is unable to suppress the DNA-damage response. Cells infected with this double-mutant virus display significant morphological heterogeneity at late times of infection. Fragmented nuclei and mitotic arrest frequently contribute to this heterogeneity.

Grantor dc:publisher

Wake Forest University

Year dc:date.issued

2013

Author dc:creator

• Turner, Roberta Lynn

• Adenovirus

Language dc:language.iso

en

Handle dc:identifier.uri

http://hdl.handle.net/10339/39131

OAI identifier oai:identifier

oai:wakespace.lib.wfu.edu:10339/39131