Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 189 for “"Adenovirus"”.
-
Mechanisms of Adenovirus-Mediated Autophagy
… to investigate other viruses, such as the adenovirus, which may be developed as part of a therapy against cancers resistant to apoptosis. Despite the present and relatively poor understanding of the mechanisms behind adenoviral-induced autophagy, adenovirus is a promising candidate, because …
-
Mechanisms of Adenovirus-Mediated Autophagy
… to investigate other viruses, such as the adenovirus, which may be developed as part of a therapy against cancers resistant to apoptosis. Despite the present and relatively poor understanding of the mechanisms behind adenoviral-induced autophagy, adenovirus is a promising candidate, because …
-
Mechanisms of Adenovirus Membrane Permeabilization
… Currently the mechanism through which adenovirus, a non-enveloped, dsDNA virus, disrupts the endosomal membrane during cell entry is not well characterized.</p><p>Recent studies suggest that adenovirus protein VI, which is released from the interior of the capsid during cell entry, has …
-
p53 activity during adenovirus infection
… vorantreiben. Zwei Onkoproteine des humanen Adenovirus Typ 5, E1B-55 kDa und E4-34 kDa, können an das p53 Protein binden und dessen Degradation begünstigen. Umgekehrt führt eine Deletion oder Mutation des Onkogens E1B-55 kDa nach Virusinfektion zu einer massiven Akkumulierung des p53 …
-
Immunomodulation in Adenovirus-Induced Viral Hepatitis
… induced hepatitis. By using an animal model of adenovirus (Ad)-induced hepatitis and in vitro studies, we explored the immune effects of these two hepatocyte survival factors and also their effects on the hepatic immune response. Project I focused on the role of IL-33. We measured its expression …
-
In vitro transcription studies of adenovirus
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1983.
-
Inactivation of adenovirus serotype 41 with monochloramine
… by a lack of safe water and sanitation. Human Adenovirus (HAdV) is a viral pathogen that persists in contaminated water and is commonly found to cause diarrhea worldwide. The United States Environmental Protection Agency has included HAdV in the Drinking Water Contaminant Candidate List 4 for …
-
Adenovirus Vectors as Potent Adjuvants in Vaccine Development
… the immune system, replication-defective Adenoviruses (Ad) are potential vaccine vectors for several pathogens. The proinflammatory response to Ad contributes to the response to vaccine antigens. We found that reactive oxygen species (ROS) are an important signal in the proinflammatory …
-
Adenovirus-based exogenous gene expression in mammalian cells
Adenoviruses have been used as a model system for understanding gene expression, DNA replication, gene delivery and other molecular biological phenomenon. In this project, adenovirus was used as a model to study exogenous gene expression in mammalian cells. More specifically, several adenoviral …
-
A Role for Mindbomb 1 in Adenovirus Genome Delivery
… factor, Mindbomb 1 (MIB1), in the context of adenovirus infection. Adenoviruses (AdVs) are widespread and highly contagious DNA viruses that can cause severe respiratory illness in children and immune-compromised individuals. An initial genome-wide loss-of-function screen to identify host …
-
Evading Innate and Adaptive Immunity During Adenovirus Cell Entry
<p>Adenovirus (Ad), a non-enveloped, dsDNA virus, enters cells via clathrin-mediated endocytosis. For viral genome delivery to the nucleus, Ad must penetrate endosomal membranes to create defects sufficient for the passage of the 90 nm diameter capsid across cell membranes. Recent observations …
-
Characterization of the Human Adenovirus 19a E3/49K Protein
Human adenoviruses (Ads) cause a variety of acute diseases but also establish persistent infections. Ads have evolved a number of mechanisms to evade the host immune response that seem to facilitate virus replication and transmission in vivo. Interestingly, one Ad transcription unit, the early …
-
UV light inactivation of adenovirus, coxsackievirus and murine norovirus
The overall objective of this research project is to evaluate the efficiency of low-pressure (LP) and medium-pressure (MP) UV light irradiation to inactivate waterborne pathogens that are an increasing concern in drinking water. The inactivation of pathogens depends directly on the total UV dose or …
Page 1 of 10