A potential biologic role for the meniscus in the development of osteoarthritis.

The overarching goal of this research is to identify the biologic role of the meniscus in the development of osteoarthritis. We hypothesized that inflammatory factors associated with joint injury would stimulate menisci to increase production of matrix-degrading enzymes, cytokines and chemokines, which could contribute to joint tissue destruction and subsequent development of osteoarthritis. We examined meniscus pathology in established osteoarthritis, characterized the alterations in meniscus cell processes between normal and osteoarthritic menisci, and explored potential pathways involved in osteoarthritis pathogenesis including a novel pathway proposed to mediate osteoarthritis development.

Grantor dc:publisher

Wake Forest University

Year dc:date.issued

2013

Author dc:creator

• Stone, Austin V.

• cartilage

Language dc:language.iso

en

Handle dc:identifier.uri

http://hdl.handle.net/10339/39030

OAI identifier oai:identifier

oai:wakespace.lib.wfu.edu:10339/39030