{"id":{"repo_id":"wfu","oai_identifier":"oai:wakespace.lib.wfu.edu:10339/39030"},"canonical_url":"https://search.dev.ndltd.org/etd/wfu/oai:wakespace.lib.wfu.edu:10339/39030","repository":{"repo_id":"wfu","name":"Wake Forest University","base_url":"https://wakespace.lib.wfu.edu/oai/request"},"display":{"title":"A potential biologic role for the meniscus in the development of osteoarthritis.","abstract":"The overarching goal of this research is to identify the biologic role of the meniscus in the development of osteoarthritis. We hypothesized that inflammatory factors associated with joint injury would stimulate menisci to increase production of matrix-degrading enzymes, cytokines and chemokines, which could contribute to joint tissue destruction and subsequent development of osteoarthritis. We examined meniscus pathology in established osteoarthritis, characterized the alterations in meniscus cell processes between normal and osteoarthritic menisci, and explored potential pathways involved in osteoarthritis pathogenesis including a novel pathway proposed to mediate osteoarthritis development.","abstract_html":"The overarching goal of this research is to identify the biologic role of the meniscus in the development of osteoarthritis. We hypothesized that inflammatory factors associated with joint injury would stimulate menisci to increase production of matrix-degrading enzymes, cytokines and chemokines, which could contribute to joint tissue destruction and subsequent development of osteoarthritis. We examined meniscus pathology in established osteoarthritis, characterized the alterations in meniscus cell processes between normal and osteoarthritic menisci, and explored potential pathways involved in osteoarthritis pathogenesis including a novel pathway proposed to mediate osteoarthritis development.","abstract_has_math":false,"creators":["Stone, Austin V."],"institution":"Wake Forest University","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2013,"date_issued":"2013","date_published":"2013","updated_at":"2026-07-27T22:01:39Z","subjects":["cartilage"],"languages":["en"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10339/39030","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Stone, Austin V."]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2013-08-23T08:35:19Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2014-02-23T09:30:12Z"]},{"key":"dc:date.issued","label":"Date","values":["2013"]},{"key":"dc:publisher","label":"Institution","values":["Wake Forest University"]},{"key":"dc:type","label":"Dc Type","values":["Dissertation"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["cartilage"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/10339/39030"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["The overarching goal of this research is to identify the biologic role of the meniscus in the development of osteoarthritis. We hypothesized that inflammatory factors associated with joint injury would stimulate menisci to increase production of matrix-degrading enzymes, cytokines and chemokines, which could contribute to joint tissue destruction and subsequent development of osteoarthritis. We examined meniscus pathology in established osteoarthritis, characterized the alterations in meniscus cell processes between normal and osteoarthritic menisci, and explored potential pathways involved in osteoarthritis pathogenesis including a novel pathway proposed to mediate osteoarthritis development."]},{"key":"dc:title","label":"Title","values":["A potential biologic role for the meniscus in the development of osteoarthritis."]}]}],"canonical_facts":{"dc:creator":["Stone, Austin V."],"dc:date.accessioned":["2013-08-23T08:35:19Z"],"dc:date.available":["2014-02-23T09:30:12Z"],"dc:date.issued":["2013"],"dc:description.abstract":["The overarching goal of this research is to identify the biologic role of the meniscus in the development of osteoarthritis. We hypothesized that inflammatory factors associated with joint injury would stimulate menisci to increase production of matrix-degrading enzymes, cytokines and chemokines, which could contribute to joint tissue destruction and subsequent development of osteoarthritis. We examined meniscus pathology in established osteoarthritis, characterized the alterations in meniscus cell processes between normal and osteoarthritic menisci, and explored potential pathways involved in osteoarthritis pathogenesis including a novel pathway proposed to mediate osteoarthritis development."],"dc:identifier.uri":["http://hdl.handle.net/10339/39030"],"dc:language.iso":["en"],"dc:publisher":["Wake Forest University"],"dc:subject":["cartilage"],"dc:title":["A potential biologic role for the meniscus in the development of osteoarthritis."],"dc:type":["Dissertation"]},"updated_at":"2026-07-27T22:01:39Z"}