Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 244 for “"biologic"”.
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Biologic effects of slow electrons
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Physics, 1936.
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Biologic therapy in patients with autoimmune arthritis /
Biological drugs (BD) have been used in the treatment of autoimmune arthritis (AA) for over 15 years. In spite of the many randomized clinical trials on BD, there is a lack of data on the special aspects of long-term application in everyday rheumatology clinical practice; for this reason the aim of …
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Biologic Influence of 900MHz Radiofrequency Identification in Rat
… to 900MHz RFID was partly changed factor of biological parameters. These changes are considered as a part of compensatory homeostatic response to the electromagnetic stress; as the changed values were still within the range of physiologic value limit, even though these are statistically …
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Preemptive variation reduction in biologic drug substance manufacturing
Biomanufacturing processes are characterized by their high natural complexity and variability, which present significant challenges to achieving consistent product quality and operational efficiency. This thesis proposes that integrating digital twins and soft sensors into these processes can …
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Physical and Biologic Properties of Calcium Silicate Endodontic Sealers
PURPOSE: To determine the cytotoxic effects, microhardness, and solubility of Endosequence BC Sealer, BioRoot RCS, NeoSEALER Flo, and BIO-C SEALER. MATERIALS AND METHODS: Nuclei counting assay and MTT assay were used to determine the cytotoxicity of the sealers at dilutions of 1:1, 1:4, and 1:32 …
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Evaluation of predictive computational modelling in biologic formulation development
… experiments and personal experience. During the biologic drug development process, proteins that target specific disease pathways are identified, developed, isolated, and purified. Scientists then conduct a series of wet-lab experiments to identify the optimal formulation that will allow the …
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Veterinary Therapeutic and Biologic Agents in Virginia Sheep Production
Biological and therapeutic agents are used in food animal production to maintain animal health and well being, prevent and treat disease, and to maintain or enhance production. Concerns about the use of pharmaceutical agents in food animal production have been raised, especially in relation to food …
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A potential biologic role for the meniscus in the development of osteoarthritis.
… goal of this research is to identify the biologic role of the meniscus in the development of osteoarthritis. We hypothesized that inflammatory factors associated with joint injury would stimulate menisci to increase production of matrix-degrading enzymes, cytokines and chemokines, which …
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Development and Characterization of Phospholipid Encapsulated Quantum Dot Constructs for Biologic Applications
… ENCAPSULATED QUANTUM DOT CONSTRUCTS FOR BIOLOGIC APPLICATIONS</p> <p>The American Cancer Society predicts that 577,190 cancer-related deaths and 1,638,910 newly diagnosed cases of cancer will occur in 2012. As these statistics show, cancer is a prevalent and devastating health issue; …
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Dried spot cards to analyse biologic fluids for diagnostic investigation of patients
Background: Collection of biologic fluid for laboratory analysis requires relatively large samples, often with additives, and transport in fragile tubes. The analytes or matrices may be unstable so testing needs to be carried out quickly. Collection of these biologic fluids and drying them on …
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Interference with biologic transmission of Anaplasma marginale by targeting the tick-pathogen interface
… challenge, (ii) interference with experimental biologic transmission of a naturally coevolved tick-borne pathogen, Anaplasma marginale, to cattle, (iii) preliminary observations of effects of tetracycline on acquisition and transmission of A. marginale by tick vectors and (iv) preliminary …
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The Physiological Aspects of the Piezoelectric Phenomenon and its Application in Biologic Bone
<p>The relationship between stress and bony architecture has long been recognized, but the actual cellular machanism which causes the alteration is still somewhat vague. Piezoelectric properties and bioelectric potentials have been proposed as partial answers.</p> <p>It is the purpose of this …
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An Analysis of Trends of Generic Drugs and Biologic Prices in the U.S.
… biosimilar market competition reduces drug and biologic prices, results in substantial savings, and improves patient access and outcomes. As the costs of healthcare and prescription drugs continue to rise, the discussion about drug prices has taken a prominent place at the forefront of national …
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Designing nanocarriers to penetrate cartilage and improve delivery of biologic drugs for osteoarthritis
Osteoarthritis is a debilitating joint disease that affects over 30 million people and has no disease-modifying therapies. The current standard of care for the disease is merely palliative until joint replacement is necessary. Disease-modifying osteoarthritis drugs have been tested in the clinic, …
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The Relationship Between Estrogen, Biologic Activity and Synthesis of Histamine in The Rat Uterus
Made available in DSpace on 2014-12-09T22:30:17Z (GMT). No. of bitstreams: 1 6812178.pdf: 3435002 bytes, checksum: ed37f77c1b612215679ee454d3f0da35 (MD5) Previous issue date: 1968
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Mechanical and Biologic Impact of Dynamic Loading on Bovine and Human Models of Osteoarthritis
Both dexamethasone (Dex) and Insulin-like growth factor 1 (IGF-1) have shown promise as disease-modifying therapeutics for osteoarthritis (OA), a disease characterized by cartilage degradation. Additionally, dynamic loading has been demonstrated to affect chondrocyte metabolic activity, with …
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Closing gaps in global access to biologic medicines : building tools to evaluate innovations in biomanufacturing
… Many NCDs are effectively treated using biologic therapies; or large molecules produced by, or involving, living cells. Recently, some of these therapies have been included on the WHO Model List of Essential Medicines. However, the molecular, manufacturing, regulatory, and supply chain …
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A Systems Approach to Understanding the History of U.S. Pediatric Biologic Drug Research and Labeling
… apply to the United States (U.S.) system for biologic drug research, development and labeling. It identifies and explains potential flaws with Hughes's LTS Theory and provides suggested improvements. As an alternative approach, this dissertation explores the concept of "techno-regulatory …
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