THE INTERPLAY BETWEEN ESTROGENS AND THE NITRIC OXIDE SYSTEM IN CARDIAC FUNCTION AND STRUCTURE

It is increasingly recognized that biological differences in the mechanisms regulating cardiovascular function in women and men critically impact the expression, clinical presentation, and outcomes of chronic diseases such as hypertension, diabetes, and heart failure. This is borne out from epidemiological and clinical studies that have explored the prevalence and presentation of heart disease in women, as well as a robust experimental literature demonstrating a role of estrogens in cardioprotection. Sex differences in mortality after myocardial infarction tell the story since data show a worse prognosis of death post-myocardial infarction for women (38% within the first year) compared to men (25% within the first year).

Grantor dc:publisher

Wake Forest University

Year dc:date.issued

2011

Author dc:creator

• Jessup, Jewell

• BH4

Language dc:language.iso

en

Handle dc:identifier.uri

http://hdl.handle.net/10339/36157

OAI identifier oai:identifier

oai:wakespace.lib.wfu.edu:10339/36157