Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 173 for “"Cardiac Function"”.
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Postsynaptic Cholinergic Control Of Cardiac Function In Aging
The present study using isolated constant flow-perfused heart from adult (8 month-old) and aged (26 month-old) Fischer 344 rats for the first time demonstrated a striking enhancement of the negative chronotropic, inotropic and coronary vasoconstriction responses of the aging heart to postsynaptic …
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Adenylyl Cyclase Type 9: Regulation and Cardiac Function
<p>Abnormalities in cardiac stress signaling underlie a number of cardiovascular diseases (e.g. arrhythmias and heart failure). Cardiac stress signaling pathways normally integrate signals from the sympathetic nervous system to promote efficient contraction and relaxation under stress. Sympathetic …
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Computational modelling of cardiac function and myocardial infarction
… infarction is a key determinant for future cardiac failure due to adverse remodelling and electrophysiological dysfunction. Computational modelling of the electrophysiology and mechanics of the heart can provide useful insights into the causes of cardiac failure and the efficacy of …
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The Direct Impact of Trimethelamine-N-Oxide on Cardiac Function
… the second chapter, the direct impact of TMAO on cardiac function was tested in vivo using wild-type C57B6L mice model. Four experiment groups were enrolled in the feeding protocol, which included 3w (different time points), 6w, and 13w feeding time to reveal the impact of short and longer periods …
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Fetal Cardiac Function and Venous Circulation - Experiences with Velocity Vector Imaging
Placental dysfunction resulting in intrauterine growth restriction (IUGR) is a common complication of pregnany and severe IUGR, with ensuing fetal hypoxia is an important cause of perinatal mortality and morbidity. Doppler studies of fetal and maternal vessels are routinely used for fetal …
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Exercise physiology and cardiac function. Aspects on determinants of maximal oxygen uptake
… in order to understand how training affects cardiac dimensions and function. Few studies have investigated the effects of training in female athletes and few have compared males and females. Therefore, the aim of this thesis was to characterize the physiologically enlarged athlete's heart and …
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Chronic Circadian Disruption Alters Behaviour, Cardiac Function and Glucose Regulation in Mice
The circadian system regulates many physiological functions including the cardiovascular system, metabolism, and stress response. Accordingly, circadian misalignment in mammals contributes to cardiometabolic disease and stress-induced emotional disorders. The BTBR mouse strain shows several …
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The influence of dietary fatty acids on cardiac function / by Salvatore Pepe
Bibliography: leaves 257-286
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ABSENCE OF V1AR ALTERS CARDIAC FUNCTION AT BASELINE AND FOLLOWING ACUTE CARDIAC INJURY
… with neurohormonal responses to the decrease in cardiac output and systemic blood pressure, such as the activation of the renin-angiotensin-aldosterone system (RAAS) and the sympathetic nervous system. Current treatment guidelines recommend using drugs that block β-adrenergic receptor (βAR) …
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THE INTERPLAY BETWEEN ESTROGENS AND THE NITRIC OXIDE SYSTEM IN CARDIAC FUNCTION AND STRUCTURE
… in the mechanisms regulating cardiovascular function in women and men critically impact the expression, clinical presentation, and outcomes of chronic diseases such as hypertension, diabetes, and heart failure. This is borne out from epidemiological and clinical studies that have explored the …
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Development of a system to measure cardiac function in the drosophila melanogaster animal model
… a number of genes have been directly linked to cardiac function and disease. The Drosophila melanogaster (Fruit Fly) has a genome similar to humans and therefore has proven to be an important animal model to study the role of genetics in cardiac function and disease development. Fruit flies are …
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Assessment of Cardiac Function by Acoustic Radiation Force (ARF) Based Methods of Ultrasound Elastography
… by compromised systolic and/or diastolic function of the myocardium that reduces the pumping and/or filling efficiency resulting in diminished cardiac output. Cardiovascular researchers have been attempting to develop tools for assessment of cardiac function for decades. Evaluating cardiac …
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Effect of metformin treatment on isolated cardiac function and blood pressure in diabetic and hypertensive rats
… of chronic metformin treatment on isolated cardiac function in rats made diabetic with STZ and secondly to explore the effect of metformin treatment on the hyperinsulinemic status of two rodent models of hypertension, the spontaneously hypertensive rat and the fructose-induced hypertensive …
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To Phosphorylate or Not to Phosphorylate: The Role of Tropomyosin Phosphorylation in Cardiac Function and Disease
… tightly regulated. Approximately 70% of total cardiac Tm phosphorylated during fetal development, decreasing to 30% during adulthood. Total Tm phosphorylation is altered in multiple mouse models of cardiac disease, including hypertrophic cardiomyopathy, dilated cardiomyopathy and myocardial …
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Interaction of exercise and simvastatin on myocardial ischemia-reperfusion (I/R) injury and post-ischemic cardiac function
… upon parameters of post-ischemic myocardial function and damage. Methods: Female Sprague-Dawley rats (6 months of age) were separated into 4 groups for a period of 4 weeks: Sedentary (S, n=10), sedentary plus 10 mg simvastatin (Zocor®)/kg body wt/ day (SD, n=9), exercise (R, n=9), and …
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Aortic Valve Replacement: The Influence of Prosthesis-Patient Mismatch for Left Ventricular Remodeling, Cardiac Function and Survival
… to recovery of left ventricular diastolic function and left ventricular mass regression, and to evaluate the influence of prosthesis-patient mismatch on left ventricular remodeling following aortic valve replacement for severe valve insufficiency. The present work demonstrated that PPM was …
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Genetic and molecular analysis of the E2F transcription factor family in mouse development, tumorigenesis, and cardiac function
… animals die at three distinct time points from cardiac etiologies. The embryonic and neonatal lethality of these animals is consistent with proliferation defects in the myocardium that result in hypoplastic heart walls and septa. E2f animals that survive the perinatal period eventually die from …
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A Novel Cardiac Function of Sumo2/3 and Senp5 Dependent Pathway and Its Physiological Impact On Congestive Cardiomyopathy
<p><strong>A Novel cardiac function of SUMO2/3 and SENP5 dependent pathway and its physiologic impact on congestive cardiomyopathy</strong></p> <p>Publication No.___________</p> <p>Eun Young Kim, M.S.</p> <p>Supervisory professor: Robert J. Schwartz, Ph.D.</p> <p>SUMOylation regulates diverse …
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