Solution Structure and Characterization of Lipid Binding of the NOXO1β PX Domain

The NADPH oxidases are multiprotein enzyme complexes which catalyze the formation of reactive oxygen species (ROS). The most studied of these is the phagocytic NADPH oxidase (PHOX), which is found in neutrophils, macrophages and monocytes. The PHOX enzyme plays a role in the host immune response through production of ROS. Deficiencies in components of the phagocytic NADPH oxidase lead to weakened host defense, as seen in chronic granulomatous disease. There are also non-phagocytic homologues of the phagocytic NADPH oxidase (NOX) found in a broad range of tissues. These homologues play roles in host defense, signaling, regulation of cell growth and metabolism. Aberrant NOX function has been implicated in several disease states such as certain cancers and Alzheimer's disease. Increased expression and dysregulation of the non-phagocytic NADPH oxidase has been indicated to have a role in abnormal growth in cancers.

Grantor dc:publisher

Wake Forest University

Year dc:date.issued

2010

Author dc:creator

• Davis, Nicole

• Lipid Binding

Language dc:language.iso

en

Handle dc:identifier.uri

http://hdl.handle.net/10339/30404

OAI identifier oai:identifier

oai:wakespace.lib.wfu.edu:10339/30404