{"id":{"repo_id":"wfu","oai_identifier":"oai:wakespace.lib.wfu.edu:10339/30404"},"canonical_url":"https://search.dev.ndltd.org/etd/wfu/oai:wakespace.lib.wfu.edu:10339/30404","repository":{"repo_id":"wfu","name":"Wake Forest University","base_url":"https://wakespace.lib.wfu.edu/oai/request"},"display":{"title":"Solution Structure and Characterization of Lipid Binding of the NOXO1β PX Domain","abstract":"The NADPH oxidases are multiprotein enzyme complexes which catalyze the formation of reactive oxygen species (ROS). The most studied of these is the phagocytic NADPH oxidase (PHOX), which is found in neutrophils, macrophages and monocytes. The PHOX enzyme plays a role in the host immune response through production of ROS. Deficiencies in components of the phagocytic NADPH oxidase lead to weakened host defense, as seen in chronic granulomatous disease. There are also non-phagocytic homologues of the phagocytic NADPH oxidase (NOX) found in a broad range of tissues. These homologues play roles in host defense, signaling, regulation of cell growth and metabolism. Aberrant NOX function has been implicated in several disease states such as certain cancers and Alzheimer's disease. Increased expression and dysregulation of the non-phagocytic NADPH oxidase has been indicated to have a role in abnormal growth in cancers.","abstract_html":"The NADPH oxidases are multiprotein enzyme complexes which catalyze the formation of reactive oxygen species (ROS). The most studied of these is the phagocytic NADPH oxidase (PHOX), which is found in neutrophils, macrophages and monocytes. The PHOX enzyme plays a role in the host immune response through production of ROS. Deficiencies in components of the phagocytic NADPH oxidase lead to weakened host defense, as seen in chronic granulomatous disease. There are also non-phagocytic homologues of the phagocytic NADPH oxidase (NOX) found in a broad range of tissues. These homologues play roles in host defense, signaling, regulation of cell growth and metabolism. Aberrant NOX function has been implicated in several disease states such as certain cancers and Alzheimer's disease. Increased expression and dysregulation of the non-phagocytic NADPH oxidase has been indicated to have a role in abnormal growth in cancers.","abstract_has_math":false,"creators":["Davis, Nicole"],"institution":"Wake Forest University","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2010,"date_issued":"2010","date_published":"2010","updated_at":"2026-07-27T22:01:07Z","subjects":["Lipid Binding"],"languages":["en"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10339/30404","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Davis, Nicole"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2011-02-16T21:42:20Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2011-08-02T08:30:10Z"]},{"key":"dc:date.issued","label":"Date","values":["2010"]},{"key":"dc:publisher","label":"Institution","values":["Wake Forest University"]},{"key":"dc:type","label":"Dc Type","values":["Dissertation"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Lipid Binding"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/10339/30404"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["The NADPH oxidases are multiprotein enzyme complexes which catalyze the formation of reactive oxygen species (ROS). The most studied of these is the phagocytic NADPH oxidase (PHOX), which is found in neutrophils, macrophages and monocytes. The PHOX enzyme plays a role in the host immune response through production of ROS. Deficiencies in components of the phagocytic NADPH oxidase lead to weakened host defense, as seen in chronic granulomatous disease. There are also non-phagocytic homologues of the phagocytic NADPH oxidase (NOX) found in a broad range of tissues. These homologues play roles in host defense, signaling, regulation of cell growth and metabolism. Aberrant NOX function has been implicated in several disease states such as certain cancers and Alzheimer's disease. Increased expression and dysregulation of the non-phagocytic NADPH oxidase has been indicated to have a role in abnormal growth in cancers."]},{"key":"dc:title","label":"Title","values":["Solution Structure and Characterization of Lipid Binding of the NOXO1β PX Domain"]}]}],"canonical_facts":{"dc:creator":["Davis, Nicole"],"dc:date.accessioned":["2011-02-16T21:42:20Z"],"dc:date.available":["2011-08-02T08:30:10Z"],"dc:date.issued":["2010"],"dc:description.abstract":["The NADPH oxidases are multiprotein enzyme complexes which catalyze the formation of reactive oxygen species (ROS). The most studied of these is the phagocytic NADPH oxidase (PHOX), which is found in neutrophils, macrophages and monocytes. The PHOX enzyme plays a role in the host immune response through production of ROS. Deficiencies in components of the phagocytic NADPH oxidase lead to weakened host defense, as seen in chronic granulomatous disease. There are also non-phagocytic homologues of the phagocytic NADPH oxidase (NOX) found in a broad range of tissues. These homologues play roles in host defense, signaling, regulation of cell growth and metabolism. Aberrant NOX function has been implicated in several disease states such as certain cancers and Alzheimer's disease. Increased expression and dysregulation of the non-phagocytic NADPH oxidase has been indicated to have a role in abnormal growth in cancers."],"dc:identifier.uri":["http://hdl.handle.net/10339/30404"],"dc:language.iso":["en"],"dc:publisher":["Wake Forest University"],"dc:subject":["Lipid Binding"],"dc:title":["Solution Structure and Characterization of Lipid Binding of the NOXO1β PX Domain"],"dc:type":["Dissertation"]},"updated_at":"2026-07-27T22:01:07Z"}