Frequency of CCR2V64I and CCR5Δ32 host genes and their association with HIV infection among pregnant women from Harare, Zimbabwe

Aim: To determine and compare the prevalence of CCR5-Δ32 and CCRV64I genes in HIV positive and HIV negative population of pregnant women from Harare, in Zimbabwe. Results: The proportion of pregnant women with the homozygous CCR2V64I gene was 24.38% and this gene was two times more associated with HIV infection than in those without it ( RR= 2.32, 95% CI-1.38-3.92). No CCR5-Δ32 deletion was detected in the studied population. Conclusion: The homozygous CCR2V64I gene and STIs were more prevalent in HIV infected pregnant women than in uninfected pregnant women and no homozygousCCR5-Δ32 gene was detected in this study.

Grantor dc:publisher.institution

University of the Western Cape

Year dc:date.issued

2010

Author dc:creator

• Soko, White

Advisor dc:contributor.advisor

• Van Wyk, Brian

• HIV in pregnant women
• Host genetic factors
• Gene polymorphism
• Mutation
• Protective effect
• CCR5-Δ32
• CCR2V64
• Vaccines
• Chemotherapeutic drugs
• Zimbabwe