Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 921 for “"Vaccines"”.
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Studies on inactivated influenza vaccines
It is, perhaps, ironical. that while influenza was probably the first animal virus to be studied in detail there is still little known concerning its behaviour. In many ways it represents a model of difficult immunization problems. Now that so many of the most lethal and dramatic of the infectious …
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DEVELOPMENT OF AVIAN PARAMYXOVIRUS VECTORED VACCINES
Avian Avulaviruses (formerly Avian Paramyxoviruses, APMV) are important pathogens of avian species and have been used as viral vectors for more than two decades. Among all APMVs, Newcastle disease virus (NDV or APMV-1) has been most extensively used as a vaccine vector for protection against avian …
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SARS-CoV-2 Variants and Vaccines
… mask wearing and social distancing. Several vaccines were rapidly developed. These included BioNTech Pfizer’s BNT162b2 mRNA-based vaccine, Moderna’s mRNA-1273 mRNA-based vaccine, and Oxford AstraZeneca’s viral vectored AZD1222 vaccine. These were administered to the public in mass vaccination …
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Development of candidate Human papillomavirus vaccines
… thesis was to investigate novel and plant-based vaccines against the Human papillomavirus type 16 (HPV-16), which is primarily responsible for cervical cancer. As a first study, the L1 gene of a South Africna variant of HPV-16 (L1 504) and a mutant (504[ΔA266T]), where the alanine at 266 was …
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Market incentives for pandemic influenza vaccines
… industry lacks clear incentives to invest in vaccines for other high-risk strains. The cyclic nature of pandemics also means we can expect another influenza pandemic within the next 20 years. In this environment, design of incentive mechanisms for funding development of vaccines against …
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Engineering kinetics of immunotherapies and vaccines
… to achieve. Secondly, “extended dosing” of vaccines – immunization regimens that prolong exposure to antigen/adjuvant– has shown promise as a strategy to significantly augment humoral immune responses to HIV vaccines. Studies in mice and non-human primates have shown that extended dosing of …
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Development of Oral Vaccines Against Lyme Disease
… the design and development of OspC-based vaccines against Lyme Disease.</p>
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SYNTHESIS AND STUDY OF ANTI-TUMOR VACCINES
<p>The inherent weak immune response against carbohydrate antigens has directed several novel approaches towards increasing their immunogenicity for their use as vaccine components. We hypothesized that conjugation of an L-rhamnose (Rha) moiety to a carbohydrate antigen would increase the immune …
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Plant-based Multicomponent Vaccines against Enteric Diseases
<p>To generate a plant-based multicomponent oral vaccine against cholera, rotavirus and enterotoxigenic E.coli (ETEC), we have constructed transgenic potato plants that synthesize the cholera toxin B and A2 subunits, the rotavirus enterotoxin NSP4 22 amino acid epitope and the ETEC fimbrial antigen …
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Development of plant-produced Bluetongue virus vaccines
… rates of livestock were reported. The only vaccines currently approved and commercially available for use are live-attenuated or inactivated virus strains and although these are effective, there is the risk of reversion in the case of live-attenuated strains to more virulent forms by …
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Development of polymeric nanoparticle vaccines for immunostimulation
Vaccines have revolutionized medicine by increasing the life expectancy of children and substantially decreasing the morbidity of multiple infectious diseases worldwide. Over several decades, we have acquired significant gains in the understanding of the underlying mechanisms involved in developing …
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New Approaches to the Development of Peptoid Vaccines
… goal of this work was to develop prophylactic vaccines that elicit such antibodies without epitope characterization. To develop such a vaccine platform, it was hypothesized that screening large one-bead-one-compound libraries of synthetic compounds with monoclonal antibodies that have already …
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Vaccines at the Intersection of Religion and Politics
… hesitancy – a delay in acceptance or refusal of vaccines despite their availability – is a rising threat to global health and has increased in recent years in higher income countries. This is a complex phenomenon with the potential to undo decades of progress toward eradicating communicable …
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Parental Perceptions of Childhood Vaccines: A Qualitative Study
<p><strong>Objective:</strong> The purpose of this study was to explore parents’ views and practices regarding routine childhood vaccination.</p> <p><strong>Background:</strong> Recently, pediatric healthcare providers have reported seeing an alarming increase in the number of families no longer …
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Antimicrobial Carbohydrate Vaccines: Development of Burkholderia pseudomallei immunogens
The potential bio-terror threat posed by Burkholderia pseudomallei highlights the need for an effective vaccine. Immunisation and challenge experiments in mice have demonstrated that the capsular polysaccharide (CPS-1) of B. pseudomallei, which is composed of β-1,3-linked …
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Development of plant-produced African horse sickness vaccines
… warming and climate change. Live attenuated vaccines (LAV) have been used with relative success for many decades, but carry the risk of reversion to virulence and/or genetic re-assortment between outbreak and vaccine strains. Furthermore, the vaccines lack DIVA capacity, the ability to …
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Characterization of avipoxviruses for use in recombinant vaccines
Pox viruses have been demonstrated in over 60 types of wild and exotic birds as well as domestic birds. Avipox viruses have been isolated and characterised from fowls, quails, canaries, parrots and lovebirds. This work describes the first isolation of a poxvirus from Jackass penguins (Spheniscus …
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