Factors affecting the excitability of skinned fibres of the rat

During the last decade, the rat mechanically skinned fibre preparation has been used with increasing frequency to investigate cellular aspects of excitation-contraction (EC) coupling processes in mammalian skeletal muscle. The main aim of this thesis was to increase awareness of factors that affect the contractile responsiveness of rat mechanically skinned fibre preparations to T-system depolarization, a functional parameter of E-C coupling referred to, sometimes, as skinned fibre excitability. More specifically, the work presented in this thesis is concerned with the relationship between rat skinned fibre excitability and (i) developmental age, (ii) MHC composition, muscle of origin and (iii) glycogen content.

Name dc:type.qualificationname

phd

Level dc:type.qualificationlevel

doctoral

Grantor dc:publisher.institution

Victoria University

Year dc:date.issued

2003

Author dc:creator

• Goodman, Craig

• 1004 Medical Biotechnology
• School of Biomedical and Health Sciences

Language dc:language

en