Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"EC coupling"”.
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Towards understanding EC coupling protein expression with age
Sarcopenia is characterised by a decrease in muscle specific force that can only partially be attributed to muscle atrophy. Changes in fiber type composition of muscle have also been observed in humans with age. Additionally, it is suggested that excitation contraction coupling (EC coupling) is …
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Towards understanding EC coupling protein expression with age
Sarcopenia is characterised by a decrease in muscle specific force that can only partially be attributed to muscle atrophy. Changes in fiber type composition of muscle have also been observed in humans with age. Additionally, it is suggested that excitation contraction coupling (EC coupling) is …
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Yeast two-hybrid analysis of skeletal muscle triad junction proteins
Excitation-contraction (EC) coupling in muscle is the process by which electrical stimulation releases calcium from the sarcoplasmic reticulum (SR), thereby allowing cross-bridge cycling between actin and myosin to occur. EC coupling occurs at specialized membrane regions called triad junctions. In …
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Role of SH3 and Cysteine-Rich Domain 3 (STAC3) in Skeletal Muscle Development, Postnatal Growth and Contraction
… rich domain 3 (Stac3) gene is expressed specifically in skeletal muscle and essential for skeletal muscle contraction and postnatal life in mice. In this dissertation project, I conducted two studies to further understand the role of STAC3 in skeletal muscle development, growth, and …
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Factors affecting the excitability of skinned fibres of the rat
During the last decade, the rat mechanically skinned fibre preparation has been used with increasing frequency to investigate cellular aspects of excitation-contraction (EC) coupling processes in mammalian skeletal muscle. The main aim of this thesis was to increase awareness of factors that affect …
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The effects of fatigue on glycogen, glycogen phosphorylase, and calcium uptake associated with the sarcoplasmic reticulum of rat skeletal muscle
… performance and rehabilitation, but it can affect one's ability to perform every day activity as well. Despite extensive investigation of muscle fatigue, little is known about the exact mechanisms that result in decreased muscle performance. It likely involves several factors that are …
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The role of extracellular matrix in modulation of myocyte Ca2+ signalling and contraction in the isolated rat heart
Traditionally the extracellular matrix (ECM) in the heart has been thought to provide mechanical scaffolding for the contracting myocytes. However, it was observed that the amplitude of the intracellular Ca2+ transients that underlie contraction was reduced in isolated myocytes in comparison to …
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Role of SLMAP in Endoplasmic Reticulum Stress and Unfolded Protein Response
Cardiac function is regulated by the molecular components of the sarco/endoplasmic reticulum (ER/SR). Disruptions in homeostatic balance of these proteins and calcium regulation results in activation of ER stress response. Sarcolemmal membrane-associated proteins (SLMAPs) are found in cell …