Abstract
dc:description.abstractIncreasing evidence suggests that overlapping genes is a common phenomenon in eukaryotic genomes too and are not restricted to prokaryotes alone. Here we determined overlapping genes in a set of orthologous genes in the genomes of human, chimp, mouse, rat, and dog and contrasted the patterns of overlapping between two principal types of overlapping genes, the same-strand-overlapping genes and different-strand-overlapping genes. The two types of overlapping genes are compared with respect to their frequencies, overlap lengths, region of overlap, and conservation of overlap in five species. Our results suggest the following: different-strand-overlaps are more common, both types show different patterns with respect to overlap lengths and regions of overlap, different-strand-overlapping genes are more evolutionarily conserved, and 3'-UTR evolution plays an important role in transitions between non-overlapping genes and overlapping genes. The thesis also presents a review of related work in terms of history, origin, types, biological significance of overlapping genes, human diseases associated with them, and their comparison in prokaryotes and eukaryotes.
Degree
thesis:*- Name thesis:degree_name
- Master of Science
- Level thesis:degree_level
- masters
- Discipline thesis:degree_discipline
- Computer Science
- Department dc:contributor.department
- Computer Science
- Grantor dc:publisher
- Virginia Tech
- Year dc:date.issued
- 2006
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Sanna, Chaitanya Ramesh
- Chair dc:contributor.committeechair
-
- Zhang, Liqing
- Committee members dc:contributor.committeemember
-
- Tu, Zhijian Jake
- Heath, Lenwood S.
Subjects
dc:subject × 5Rights
dc:rights- Statement dc:rights
-
- In Copyright
- Licence dc:rights.uri
- Language dc:language.iso
- en
Identifiers
dc:identifier.*- Dc Identifier Other
- etd-07102006-161019
- OAI identifier oai:identifier
- oai:vtechworks.lib.vt.edu:10919/43601