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Virginia Tech
Baculovirus-directed expression of the phosphorylase kinase catalytic subunit: pseudosubstrate and calmodulin regulation
Abstract
dc:description.abstractPhosphorylase kinase (EC 2.7.1.38) is a key enzyme involved in the regulation of the glycogenolysis pathway. It catalyzes the Ca²⁺-dependent phosphorylation and activation of the enzyme glycogen phosphorylase to make the active form glycogen phosphorylase. Phosphorylase kinase is composed of 4 subunits with a stoichiometry of (αβγδ)₄. The γ subunit is the catalytic subunit. The regulatory domain (residues 277-387) of γ contains a sequence resembling the sites phosphorylated in known γ substrates with the exception that a valine₃₃₂ occurs at the analogous position of the phosphorylated serine or threonine residue.
Degree
thesis:*- Name thesis:degree_name
- Ph. D.
- Level thesis:degree_level
- doctoral
- Discipline thesis:degree_discipline
- Biochemistry and Anaerobic Microbiology
- Department dc:contributor.department
- Biochemistry and Anaerobic Microbiology
- Grantor dc:publisher
- Virginia Tech
- Year dc:date.issued
- 1994
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Lanciotti, Robert Arthur
- Chair dc:contributor.committeechair
-
- Bender, Patrick K.
- Committee members dc:contributor.committeemember
-
- Bevan, David R.
- Kennelly, Peter J.
- Lederman, Muriel L.
- Potts, Malcolm
Rights
dc:rights- Statement dc:rights
-
- In Copyright
- Licence dc:rights.uri
- Language dc:language.iso
- en
Identifiers
dc:identifier.*- Dc Identifier Other
- etd-06062008-163955
- OAI identifier oai:identifier
- oai:vtechworks.lib.vt.edu:10919/38252