Physical Concepts of Copolymerization of Microtubules in the Presence of Anti-mitotic Agents

A mathematical approach to the concepts of copolymerization of microtubules in the presence of anti-mitotic drugs is presented in this work. A general feature of the mathematical equations is presented. The possibility of having analytical steady state solutions of dynamic equations is investigated. The structure of equations is narrowed down for the specific brand of anti-mitotic drug, colchicine. The behavior of total T-tubulin concentration in the steady state in a regeneration system is investigated and analyzed through the numerical calculations.

Name thesis:degree_name

Ph. D.

Level thesis:degree_level

doctoral

Discipline thesis:degree_discipline

Physics

Department dc:contributor.department

Physics

Grantor dc:publisher

Virginia Tech

Year dc:date.issued

2005

Author dc:creator

• Shojania Feizabadi, Mitra

Chair dc:contributor.committeechair

• Spillman, William B. Jr.

Committee members dc:contributor.committeemember

• Mizutani, Tetsuro
• Indebetouw, Guy J.
• Walker, Richard A.
• Ritter, Alfred L.

• antimitotic drugs
• dynamic instability
• microtubule

Statement dc:rights

• In Copyright

Licence dc:rights.uri

• http://rightsstatements.org/vocab/InC/1.0/

Dc Identifier Other

etd-05192005-104254

OAI identifier oai:identifier

oai:vtechworks.lib.vt.edu:10919/27795