{"id":{"repo_id":"vt","oai_identifier":"oai:vtechworks.lib.vt.edu:10919/27795"},"canonical_url":"https://search.dev.ndltd.org/etd/vt/oai:vtechworks.lib.vt.edu:10919/27795","repository":{"repo_id":"vt","name":"Virginia Tech","base_url":"https://vtechworks.lib.vt.edu/oai/request"},"display":{"title":"Physical Concepts of Copolymerization of Microtubules in the Presence of Anti-mitotic Agents","abstract":"A mathematical approach to the concepts of copolymerization of microtubules in the presence of anti-mitotic drugs is presented in this work. A general feature of the mathematical equations is presented. The possibility of having analytical steady state solutions of dynamic equations is investigated. The structure of equations is narrowed down for the specific brand of anti-mitotic drug, colchicine. The behavior of total T-tubulin concentration in the steady state in a regeneration system is investigated and analyzed through the numerical calculations.","abstract_html":"A mathematical approach to the concepts of copolymerization of microtubules in the presence of anti-mitotic drugs is presented in this work. A general feature of the mathematical equations is presented. The possibility of having analytical steady state solutions of dynamic equations is investigated. The structure of equations is narrowed down for the specific brand of anti-mitotic drug, colchicine. The behavior of total T-tubulin concentration in the steady state in a regeneration system is investigated and analyzed through the numerical calculations.","abstract_has_math":false,"creators":["Shojania Feizabadi, Mitra"],"institution":"Virginia Tech","degree_name":"Ph. D.","degree_level":"doctoral","degree_discipline":"Physics","degree_department":"Physics","school":null,"contributors":[],"advisors":[],"committee_chairs":["Spillman, William B. Jr."],"committee_members":["Mizutani, Tetsuro","Indebetouw, Guy J.","Walker, Richard A.","Ritter, Alfred L."],"year":2005,"date_issued":"2005-04-29","date_published":"2005-04-29","updated_at":"2026-07-22T22:19:49Z","subjects":["antimitotic drugs","dynamic instability","microtubule"],"languages":[],"rights":["In Copyright"],"rights_urls":["http://rightsstatements.org/vocab/InC/1.0/"],"identifier_entries":[{"key":"dc:identifier.other","label":"Dc Identifier Other","values":["etd-05192005-104254"],"render_values":[{"text":"etd-05192005-104254","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/10919/27795","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.committeechair","label":"Committee Chair","values":["Spillman, William B. Jr."]},{"key":"dc:contributor.committeemember","label":"Committee Member","values":["Mizutani, Tetsuro","Indebetouw, Guy J.","Walker, Richard A.","Ritter, Alfred L."]},{"key":"dc:contributor.department","label":"Department","values":["Physics"]},{"key":"dc:creator","label":"Author","values":["Shojania Feizabadi, Mitra"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2014-03-14T20:12:16Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2014-03-14T20:12:16Z","2008-06-24"]},{"key":"dc:date.issued","label":"Date","values":["2005-04-29"]},{"key":"dc:publisher","label":"Institution","values":["Virginia Tech"]},{"key":"dc:type","label":"Dc Type","values":["Dissertation"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Physics"]},{"key":"thesis:degree_level","label":"Degree Level","values":["doctoral"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph. D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["Virginia Polytechnic Institute and State University"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["antimitotic drugs","dynamic instability","microtubule"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:rights","label":"Dc Rights","values":["In Copyright"]},{"key":"dc:rights.uri","label":"Rights URI","values":["http://rightsstatements.org/vocab/InC/1.0/"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.other","label":"Dc Identifier Other","values":["etd-05192005-104254"]},{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/10919/27795"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["A mathematical approach to the concepts of copolymerization of microtubules in the presence of anti-mitotic drugs is presented in this work. A general feature of the mathematical equations is presented. The possibility of having analytical steady state solutions of dynamic equations is investigated. The structure of equations is narrowed down for the specific brand of anti-mitotic drug, colchicine. The behavior of total T-tubulin concentration in the steady state in a regeneration system is investigated and analyzed through the numerical calculations."]},{"key":"dc:description.degree","label":"Dc Description Degree","values":["Ph. D."]},{"key":"dc:title","label":"Title","values":["Physical Concepts of Copolymerization of Microtubules in the Presence of Anti-mitotic Agents"]}]}],"canonical_facts":{"dc:contributor.committeechair":["Spillman, William B. Jr."],"dc:contributor.committeemember":["Mizutani, Tetsuro","Indebetouw, Guy J.","Walker, Richard A.","Ritter, Alfred L."],"dc:contributor.department":["Physics"],"dc:creator":["Shojania Feizabadi, Mitra"],"dc:date.accessioned":["2014-03-14T20:12:16Z"],"dc:date.available":["2014-03-14T20:12:16Z","2008-06-24"],"dc:date.issued":["2005-04-29"],"dc:description.abstract":["A mathematical approach to the concepts of copolymerization of microtubules in the presence of anti-mitotic drugs is presented in this work. A general feature of the mathematical equations is presented. The possibility of having analytical steady state solutions of dynamic equations is investigated. The structure of equations is narrowed down for the specific brand of anti-mitotic drug, colchicine. The behavior of total T-tubulin concentration in the steady state in a regeneration system is investigated and analyzed through the numerical calculations."],"dc:description.degree":["Ph. D."],"dc:identifier.other":["etd-05192005-104254"],"dc:identifier.uri":["http://hdl.handle.net/10919/27795"],"dc:publisher":["Virginia Tech"],"dc:rights":["In Copyright"],"dc:rights.uri":["http://rightsstatements.org/vocab/InC/1.0/"],"dc:subject":["antimitotic drugs","dynamic instability","microtubule"],"dc:title":["Physical Concepts of Copolymerization of Microtubules in the Presence of Anti-mitotic Agents"],"dc:type":["Dissertation"],"thesis:degree_discipline":["Physics"],"thesis:degree_level":["doctoral"],"thesis:degree_name":["Ph. D."],"thesis:institution_name":["Virginia Polytechnic Institute and State University"]},"updated_at":"2026-07-22T22:19:49Z"}