Examining Alcohol Dependence and Its Correlates From A Genetically Informative Perspective

Alcohol dependence (AD) is a serious and common public health problem that contributes to great societal, medical, and legal costs. It has taken work from multiple disciplines, including developmental psychology, genetic epidemiology, and molecular genetics, to achieve our current understanding of environmental and genetic risk factors for AD as well as its variable developmental trajectories. Nevertheless, there is still much to be learned in order to improve treatment outcomes. One approach to augmenting our understanding of this disorder is through genetically informative study designs that either examine risk in aggregate or assess specific susceptibility variants. In this dissertation, we utilize both study designs and provide support for the idea that they are both important and useful approaches to continue to pursue.

Name thesis:degree_name

Doctor of Philosophy

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Human Genetics

Year dc:date.available

2012

Author dc:creator

• Hack, Laura

Contributors dc:contributor

• Brien Riley
• Kenneth Kendler

• alcohol dependence
• alcoholic beverage preference
• externalizing factor score
• gene-environment interaction
• GWAS
• twin study
• Medical Genetics
• Medical Sciences
• Medicine and Health Sciences

Statement dc:rights

• © The Author

Identifier

https://scholarscompass.vcu.edu/etd/547

OAI identifier oai:identifier

oai:scholarscompass.vcu.edu:etd-1546