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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 331 for “"GWAS"”.
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Optimizing GWS and GWAS in crop breeding
… of interest. Genome- wide association studies (GWAS) have also been widely used, it aims to identify causal variants to detect significant associations between genetic markers and traits of interest. In the first chapter, predictions based on pedigree information, molecular markers and cassava …
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Bayesian Network Modeling and Inference of GWAS Catalog
<p>Genome-wide association studies (GWASs) have received an increasing attention to understand genotype-phenotype relationships. The Bayesian network has been proposed as a powerful tool for modeling single-nucleotide polymorphism (SNP)-trait associations due to its advantage in addressing the high …
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Mitochondrial Contributions to Schizophrenia Symptom Severity: A GWAS Approach in a South African Population
Schizophrenia (SCZ) is increasingly recognized as a disorder of compromised brain bioenergetics. Therefore, this study investigated the contribution of mitochondrial genomic variation and mitonuclear crosstalk to clinical symptom severity in a South African First Episode Schizophrenia (FES) cohort …
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The Molecular Mechanism Of The Gwas Association Of The Slc22a1 Locus With Metabolic Traits
… unexplored. Genome-wide association studies (GWASs) have revealed novel associations at the SLC22A1 locus for plasma acylcarnitine and low-density lipoprotein (LDL) cholesterol levels, suggesting previously unknown roles of SLC22A1 in the regulation of acylcarnitine and cholesterol metabolism. …
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Linkage fine-mapping, GWAS and QTLs affecting morpho-agronomic traits of a common bean RIL population
… is the genome wide association study (GWAS). In this context, the Common Bean Breeding Program of the Universidade Federal de Viçosa (UFV) developed a population consisting of 376 RILs, obtained from the crossing between Rudá and AND 277, to construct a genetic map and detect QTLs …
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Evaluation of genomic prediction models that incorporates peak GWAS signals in maize and sorghum diversity panels
… used in a genome-wide association study (GWAS) and genomic selection (GS) quantify the contributions of genomic markers in linkage disequilibrium with these genes to trait variation. In general, the GWAS has been successful at identifying genomic regions containing markers with moderate to …
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SAERMA: Stacked Autoencoders Rule Mining Algorithm for the Interpretation of Epistatic Interactions in GWAS of Extreme Obesity
… (SNPs). Genome-wide association studies (GWAS), are the state-of-the-art in identifying genetic variants for complex disorders, such as obesity. However, GWAS use single-locus analysis where each SNP is independently tested for association with some phenotype. The limitation of genetic …
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C6 and C9 volatile compounds in 223 cucumbers (cucumis sativus L.) In Genome-Wide Association Studies (GWAS)
… aimed to quantify C6 and C9 compounds in 223 GWAS cucumber varieties. A comprehensive analysis of volatiles was performed using solid-phase microextraction gas chromatography-mass spectrometry (SPME-GC-MS). Hexenal (1.27–15.28 ppm) was the predominant volatile, followed by (E)-2-hexenal …
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Combining genotyping-by-sequencing data sets for GWAS and GWS study for maize root System architecture traits
… water. Tools such as genome-wide association (GWAS) and genome-wide selection (GWS) can help the breeders to make decisions about which genotypes should advance in their breeding programs. In this work, we combined two data sets with different genetic backgrounds to perform a GWAS and GWS …
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Quantification of sugars and organic acids in 210 cucumber (cucurbis sativus) varieties for genome-wide association studies (GWAS)
… acid contents in Genome-Wide Association Study (GWAS) cucumbers. This study aimed to measure total soluble solid content (ºBrix), three main sugars via high-performance liquid chromatography (HPLC), pH, titratable acidity (TA), and three main organic acids via HPLC in 210 GWAS cucumber samples. A …
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Estratégia de indução de déficit hídrico em soja e desenvolvimento de GWAS para germinação e vigor de sementes
… de vegetação. Posteriormente, com o auxílio de GWAS, explorar a associação entre SNPs e características de interesse relacionadas à germinação e dinâmica de reservas de sementes em diferentes condições de estresse, para seu potencial uso no melhoramento genético. Para isso foi realizado uma …
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The Expression Profile of A Gwas Detected Gene (Ninj2) In The Brain of A Mouse Model of Ischemic Stroke
… of the disease. Genome-wide association studies (GWAS) have contributed to the identification of genetic loci influencing risk for complex diseases, such as stroke. In 2010, a GWAS of incident stroke was performed in four large prospective cohorts from the USA and Europe and identified an …
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Integrative statistical methods for the genomic analysis of immune-mediated disease
Genome-wide association studies (GWAS) have proved to be a successful method in cataloguing loci influencing thousands of complex human disease phenotypes. However, elucidating the causal mechanisms underlying such associations has proved challenging due to the regulatory nature of the majority of …
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Disease population genetic simulation framework: towards application in modelling disease risk prediction and heritability rate
… since the first genome-wide association study (GWAS) was conducted. The field has since experienced monumental strides, as evidenced by over half a million associations submitted in the GWAS catalog today, advancements in sequencing technologies, and the development of robust methodologies for …
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Computational methods to dissect the genetic basis of human disease
Genome-wide association studies (GWAS) have been successful in identifying disease-associated genetic variants. However, the path from GWAS to biological insight remains challenging, notably in identifying relevant biological pathways, explaining mechanistic links between diseases, and nominating …
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Improving Clinical Risk Models through Integration of Polygenic Risk Scores and Omics
Genome-wide association studies (GWAS) have significantly contributed to the identification of genetic variants by leveraging thousands of loci associated with complex traits and diseases, leading to breakthroughs in human genetics research. However, interpretation of these results is often …
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Multi-omics Investigation into Alzheimer's Disease: Functional Mechanism and Early Detection
… statistics from genome-wide association study (GWAS) and expression quantitative trait loci (eQTL) analysis. Results of this study confirmed the potential of integrative GWAS and eQTL analysis in estimating the transcriptomic changes when lack of tissue-specific expression data, and provided …
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Genetic factors associated with neuropathic pain
… a discovery genome-wide association study (GWAS) of NP was performed in Genetics of Diabetes Audit and Research in Tayside Scotland (GoDARTS) and replication of significant findings was tested in United Kingdom Biobank (UKBB) cohort using dispensed medication records. Thirdly, NP cases and …
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Towards constructing disease relationship networks using genome-wide association studies
Background: Genome-wide association studies (GWAS) prove to be a powerful approach to identify the genetic basis of various human[1] diseases. Here we take advantage of existing GWAS data and attempt to build a framework to understand the complex relationships among diseases. Specifically, we …
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Pleiotropy in complex traits
Genome-wide association studies (GWAS) have uncovered thousands of complex trait loci, many of which are associated with multiple phenotypes. The dedicated study of these pleiotropic effects is becoming increasingly common due to the availability of sample collections with high-dimensional …
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