{"id":{"repo_id":"vcu","oai_identifier":"oai:scholarscompass.vcu.edu:etd-1546"},"canonical_url":"https://search.dev.ndltd.org/etd/vcu/oai:scholarscompass.vcu.edu:etd-1546","repository":{"repo_id":"vcu","name":"Virginia Commonwealth University","base_url":"https://scholarscompass.vcu.edu/do/oai/"},"display":{"title":"Examining Alcohol Dependence and Its Correlates From A Genetically Informative Perspective","abstract":"Alcohol dependence (AD) is a serious and common public health problem that contributes to great societal, medical, and legal costs. It has taken work from multiple disciplines, including developmental psychology, genetic epidemiology, and molecular genetics, to achieve our current understanding of environmental and genetic risk factors for AD as well as its variable developmental trajectories. Nevertheless, there is still much to be learned in order to improve treatment outcomes. One approach to augmenting our understanding of this disorder is through genetically informative study designs that either examine risk in aggregate or assess specific susceptibility variants. In this dissertation, we utilize both study designs and provide support for the idea that they are both important and useful approaches to continue to pursue.","abstract_html":"Alcohol dependence (AD) is a serious and common public health problem that contributes to great societal, medical, and legal costs. It has taken work from multiple disciplines, including developmental psychology, genetic epidemiology, and molecular genetics, to achieve our current understanding of environmental and genetic risk factors for AD as well as its variable developmental trajectories. Nevertheless, there is still much to be learned in order to improve treatment outcomes. One approach to augmenting our understanding of this disorder is through genetically informative study designs that either examine risk in aggregate or assess specific susceptibility variants. In this dissertation, we utilize both study designs and provide support for the idea that they are both important and useful approaches to continue to pursue.","abstract_has_math":false,"creators":["Hack, Laura"],"institution":null,"degree_name":"Doctor of Philosophy","degree_level":"Dissertation","degree_discipline":"Human Genetics","degree_department":null,"school":null,"contributors":["Brien Riley","Kenneth Kendler"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2012,"date_issued":"2012-09-28T07:00:00Z","date_published":"2012-09-28T07:00:00Z","updated_at":"2026-07-24T05:54:02Z","subjects":["alcohol dependence","alcoholic beverage preference","externalizing factor score","gene-environment interaction","GWAS","twin study","Medical Genetics","Medical Sciences","Medicine and Health Sciences"],"languages":[],"rights":["© The Author"],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["https://scholarscompass.vcu.edu/etd/547"],"render_values":[{"text":"https://scholarscompass.vcu.edu/etd/547","href":"https://scholarscompass.vcu.edu/etd/547","code":true}]}]},"links":{"outbound_url":"https://doi.org/10.25772/PVQZ-D245","outbound_label":"DOI","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Brien Riley","Kenneth Kendler"]},{"key":"dc:creator","label":"Author","values":["Hack, Laura"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.available","label":"Dc Date Available","values":["2018-10-02T07:00:00Z"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Human Genetics"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Doctor of Philosophy"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["alcohol dependence","alcoholic beverage preference","externalizing factor score","gene-environment interaction","GWAS","twin study","Medical Genetics","Medical Sciences","Medicine and Health Sciences"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:rights","label":"Dc Rights","values":["© The Author"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://doi.org/10.25772/PVQZ-D245","https://scholarscompass.vcu.edu/etd/547"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Alcohol dependence (AD) is a serious and common public health problem that contributes to great societal, medical, and legal costs. It has taken work from multiple disciplines, including developmental psychology, genetic epidemiology, and molecular genetics, to achieve our current understanding of environmental and genetic risk factors for AD as well as its variable developmental trajectories. Nevertheless, there is still much to be learned in order to improve treatment outcomes. One approach to augmenting our understanding of this disorder is through genetically informative study designs that either examine risk in aggregate or assess specific susceptibility variants. In this dissertation, we utilize both study designs and provide support for the idea that they are both important and useful approaches to continue to pursue."]},{"key":"dc:title","label":"Title","values":["Examining Alcohol Dependence and Its Correlates From A Genetically Informative Perspective"]}]}],"canonical_facts":{"dc:contributor":["Brien Riley","Kenneth Kendler"],"dc:creator":["Hack, Laura"],"dc:date.available":["2018-10-02T07:00:00Z"],"dc:description.abstract":["Alcohol dependence (AD) is a serious and common public health problem that contributes to great societal, medical, and legal costs. It has taken work from multiple disciplines, including developmental psychology, genetic epidemiology, and molecular genetics, to achieve our current understanding of environmental and genetic risk factors for AD as well as its variable developmental trajectories. Nevertheless, there is still much to be learned in order to improve treatment outcomes. One approach to augmenting our understanding of this disorder is through genetically informative study designs that either examine risk in aggregate or assess specific susceptibility variants. In this dissertation, we utilize both study designs and provide support for the idea that they are both important and useful approaches to continue to pursue."],"dc:identifier":["https://doi.org/10.25772/PVQZ-D245","https://scholarscompass.vcu.edu/etd/547"],"dc:rights":["© The Author"],"dc:subject":["alcohol dependence","alcoholic beverage preference","externalizing factor score","gene-environment interaction","GWAS","twin study","Medical Genetics","Medical Sciences","Medicine and Health Sciences"],"dc:title":["Examining Alcohol Dependence and Its Correlates From A Genetically Informative Perspective"],"thesis:degree_discipline":["Human Genetics"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Doctor of Philosophy"]},"updated_at":"2026-07-24T05:54:02Z"}