Apoptosis and Necroptosis in Renal Cell Carcinoma // Апоптоза и некроптоза при бъбречноклетъчен карцином

RCC incidence and mortality have shown a constant tendency to increase worldwide over the years. Currently, known standard approaches for renal cell carcinoma treatment are insufficient in some cases due to resistance to chemo- and radiotherapy. Pathway activation of one or another form of cell death can be used in the search for new approaches in renal cell carcinoma treatment. There is evidence in the literature that renal carcinoma tumour cells are resistant to the intrinsic and extrinsic pathways of apoptosis. Apoptosis is programmed cell death that can also occur via another, alternative pathway that is caspase-independent and involves AIF. The role of AIF in renal cell carcinoma is poorly studied and additional research is needed, which is why it was the object of the present study. Another form of cell death is necroptosis. A key participant in the process is RIPK3, which is known to have both tumor-stimulating and tumor-suppressive functions in different tumors. Further in-depth studies are needed on the role of RIPK3 in tumour development, progression, metastases, and recurrence, as well as anti-tumour immunity in renal cell carcinoma, and its correlation with clinical-morphological indicators.

Grantor dc:publisher

Medical University of Varna

Year dc:date

2025

Authors dc:creator

• Yanulova, Nevena
• Янулова, Невена

• renal cell carcinoma
• apoptosis
• necroptosis
• resistance to chemo- and radiotherapy
• Патологоанатомия и цитопатология / Pathological anatomy and cytopathology

Repository record dc:identifier

http://repository.mu-varna.bg/handle/nls/3965

OAI identifier oai:identifier

oai:repository.mu-varna.bg:nls/3965