Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 37 for “"AIF"”.
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UNDERSTANDING THE PRO-SURVIVAL ROLE OF AIF: STRUCTURAL AND FUNCTIONAL STUDY OF AIF-CHCHD4 COMPLEX
Il fattore di induzione dell’apoptosi (AIF), una flavoproteina mitocondriale altamente conservata, è generalmente noto per il suo ruolo nell’attivazione del processo di apoptosi intrinseca in maniera indipendente dalle caspasi. Oltre a questa funzione pro-apoptotica, studi recenti hanno dimostrato …
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The Interplay between Technology, Tactics and Organisation in the First AIF
… tactics and organisation of the First AIF. Warfare in the twentieth warfare is characterised by the presence of certain technologies that give it a distinctive nature and which first appeared in the Great War. It was in the Great War that the highly dispersed form of tactics that we …
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'An army of warriors, these Anzacs' : legend and illusion in the first AIF
This dissertation is principally concerned with two myths about the experience and character of Australia's Great War soldiers central to the Anzac legend. The first is the myth of egalitarianism; the second is the myth of the resourcefulness and initiative of Australian soldiers. It argues that …
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THE PROSURVIVAL ACTIVITIES OF APOPTOSIS-INDUCING FACTOR CONVERGE UPON THE REGULATION OF MITOCHONDRIAL METABOLISM, A NOVEL CELL DEATH PATHWAY, AND THE PROGRESSION OF PROSTATE CANCER
Apoptosis-inducing factor (AIF) is a mitochondrial NADH-oxidase originally discovered for its ability to trigger apoptosis through chromatin condensation and DNA cleavage. Although AIF is recognized for its apoptotic function, AIF-mediated cell death has emerged as an atypical cell death pathway; …
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Absolute tumor perfusion determined by nuclear magnetic resonance spectroscopy :
… to obtain absolute perfusion measures, and the AIF is required for this, Chapter II discusses the development of the apparatus and NMR method with which one can extract an apparent AIF from individual rats - a method which will not necessarily result in the animal's immediate death. As a further …
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Statistical modeling strategies for estimation of the arterial input function in dynamic positron emission tomography data analysis
… described by the arterial input function (AIF). Arterial blood sampling is the gold standard for AIF measurement, but is invasive and labour intensive. A number of methods have been proposed to accurately estimate the AIF directly from blood sampling and/or imaging data. In this work, we …
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High-Throughput Screening Development Using Photonic-Crystal Optical Biosensor
… (the human apoptosis inducing factor (AIF)). The PC technology was further utilized in a screen for inhibitors of the AIF-DNA interaction, and through this screen aurin tricarboxylic acid (ATA) was identified as the first in vitro inhibitor of AIF. The generality and simplicity of the …
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Impacts of perfluorooctanoic acid on porcine oocyte health and competence
… dismutase (SOD1), apoptosis inducing factor (AIF), and BCL 2 associated X protein (BAX). We hypothesized that oxidative stress and apoptotic pathways would be affected by PFOA during the meiotic maturation period, and that co-exposure with albumin would mitigate these effects. To test this …
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Improved quantification in small animal PET/MR
… estimates of the arterial input function (AIF), which defines the amount of PET tracer within blood plasma over time. The AIF is required to produce physiological parameters quantifying key processes such as metabolism or perfusion from dynamic PET images. The gold standard for AIF …
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Automated perfusion-weighted MRI metrics via localized arterial input functions
… metrics by defining an arterial input function (AIF) for every voxel in the brain based upon the voxels in close proximity to it. This allows for automated calculation of perfusion metrics, and the localized nature of the AIFs creates an implicit regard for delay and dispersion. This thesis …
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The discovery of small molecule inhibitors of poly(ADP-ribose) mediated cell death
… degrades PAR, and apoptosis inducing factor (AIF), a protein that orchestrates stage I chromatin condensation. Recognizing that the phosphate moiety, which is cell impermeable, is necessary for PARG recognition and binding, Chapter 2 describes how small molecules containing the rhodanine …
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Apoptosis and Necroptosis in Renal Cell Carcinoma // Апоптоза и некроптоза при бъбречноклетъчен карцином
… pathway that is caspase-independent and involves AIF. The role of AIF in renal cell carcinoma is poorly studied and additional research is needed, which is why it was the object of the present study. Another form of cell death is necroptosis. A key participant in the process is RIPK3, which is …
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The role of multinational corporations in UK sustainable development policy
… developed and tested within this thesis. The AIF has drawn together insights from a wide-ranging debate surrounding power and influence, marrying the dimensions of power with those relating to deliberation and discourse. The AIF has been used within a multi-method approach consisting of; …
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Cyber-Physical-Social Systems for Autonomous Defense: Enabling Mission-Centric, Adaptive, and Anytime Intelligence
… Response Systems (IRS), and Anytime Inference (AIF), that collectively advance trustworthy decision-making under adversarial, uncertain, and resource-constrained conditions. Rather than functioning as isolated contributions, these tasks form a seamless progression: MIA quantifies mission risk …
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Cellular pathology and apoptosis in experimental and human acute and chronic compressive myelopathy.
… and below the site at 3 weeks. Caspase-9, PARP, AIF and active caspase-3 staining was found in glia at, above and below the site in all groups. Caspase-3 was greater expressed in the 24 hour (mean 0.32, p = 0.01) and 3 week (mean 0.31, p = 0.02) decompression groups when compared with the 9 week …
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Degenerative mechanism in dopaminergic neurons
… also demonstrated a time-dependent release of AIF, a mitochondrial-located protein capable of inducing cell death, into the cytosol. This suggests that AIF might indeed be a part of this alternative death pathway induced in MPP+-challenged MN9D cells. Preliminary results also showed the …
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The analysis of dynamic contrast-enhanced magnetic resonance imaging data: treatment effects, sampling rates and repeatability
… an accurate and precise arterial input function (AIF) is reviewed, as are current proposed solutions. The general principles underlying the implementation of a customised software analysis package for the analysis of DCE-MRI data are described. Data from studies involving four different human …
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Advancing Efficiency and Safety in Autonomous Sequential Decision Making
… framework that integrates active inference (AIF), based on the free energy principle, with RL in continuous-space POMDPs is introduced. By emphasizing the minimization of expected free energy (EFE), AIF augments RL, enhancing decision making in the face of state uncertainty. This approach …
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Reactive Oxygen Species-Induced Necrotic Cell Death
… the translocation of apoptosis-inducing factor (AIF) from mitochondria to the nucleus, a process usually associated with PARP-dependent cell death. Inhibition of PARP-1 with PJ34 blocked TGHQ-mediated accumulation of poly(ADP-ribose) polymers, NAD consumption, and the consequent necrotic cell …
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Modélisation pharmacocinétique combinée IRM-TEP
… le sang, nommée fonction d'entrée artérielle (AIF). Toutefois, cette dernière est difficile à mesurer. En IRM, pour la modélisation, il existe un compromis à faire entre la résolution spatiale et la résolution temporelle. Dans ce mémoire, une approche pour convertir l'AIF d'une modalité à …
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