Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 45 for “"necroptosis"”.
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Optogenetic control of necroptosis pathway
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-08-01
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The Role of CK1 in Necroptosis and Confirmation of Amyloid-Like Fibers in Necroptosis Using 2D SDD-AGE
Necroptosis is a regulated necrotic cell death pathway, mediated by a supermolecular complex called the necrosome, which contains receptor-interacting protein kinase 1 and 3 (RIPK1, RIPK3) and mixed-lineage kinase domain-like protein (MLKL). Phosphorylation of human RIPK3 at serine 227 (S227) has …
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Characterisation of Novel Autophagy and Necroptosis Antagonists Encoded by Human Cytomegalovirus
… of two critical host responses—autophagy and necroptosis—by combining comprehensive proteomic screening with conventional biochemical assays. The initial focus was on lysosomal acidification, a process essential for autophagic cargo degradation. By overlapping quantitative proteomic data from …
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Apoptosis and Necroptosis in Renal Cell Carcinoma // Апоптоза и некроптоза при бъбречноклетъчен карцином
… the present study. Another form of cell death is necroptosis. A key participant in the process is RIPK3, which is known to have both tumor-stimulating and tumor-suppressive functions in different tumors. Further in-depth studies are needed on the role of RIPK3 in tumour development, progression, …
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The Role of Necroptosis in Inflammatory Bowel Disease // Ролята на некроптозата при възпалителните чревни заболявания
Възпалителните заболявания на червата са заболявания, чиято честота се увеличава все повече, засягат предимно млади хора, а еволюцията им през целия живот води до значимо нарушение на функцията на гастроинтестиналния тракт с последващи тежки увреждания. Това влошава качеството на живот на …
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Loss of Caspase-8 Function In Combination With Smac Mimetic Treatment Sensitizes Head and Neck Squamous Carcinoma to Radiation Through Induction of Necroptosis.
… has been reported to sensitize cancer cells to necroptosis, a unique cell death mechanism. Here, we evaluated how CASP8 regulates necroptosis in HSNCC using cell line models and syngeneic mouse xenografts. <em>In vitro</em>, knockdown of CASP8 rendered HNSCCs susceptible to necroptosis induced …
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Expression of Markers for Autophagy and Necroptosis in Colorectal Carcinoma // Експресия на маркери за автофагия и некроптоза при дебелочревен карцином
Колоректалният карцином (КРК) е злокачествено заболяване, чиято честота в последните години непрекъснато нараства. През последните години бяха разработени редица обещаващи туморни маркери, допринасящи за ранното диагностициране, прогностична оценка и мониториране на заболяването. При пациенти с КРК …
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Exploring The Relationship Between Mitochondrial-linked Cell Death And Muscle Atrophy During Ovarian Cancer Progression
… hydrogen peroxide (mH2O2)-mediated apoptosis and necroptosis in muscle atrophy using an orthotopic epithelial ovarian cancer (EOC) model at 40 and 80 days of tumor progression. We also examined the effects of the mitochondrial-targeted antioxidant SkQ1 on mH2O2 levels, regulation of apoptosis and …
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RIP3 Marker Expression for Necroptosis in Cases of Prostate Cancer // Експресия на маркер за некроптоза RIP3 в случаи на простатен карцином
Целта на това проучване е да се изследва и оцени експресията на маркера за некроптоза RIP3 в туморната тъкан на простатен карцином във връзка с клинико-патологичните показатели и да се определи прогностичната му и предиктивна стойност за преживяемостта на пациентите. За тази цел се анализираха …
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Apoptosis and Necroptosis in Basal Cell and Spinocellular Carcinoma of the Skin // Апоптоза и некроптоза при базоцелуларен и спиноцелуларен карцином на кожа
… the efficacy of malignant neoplasm treatment. Necroptosis is a type of cell death that has features of both apoptosis and necrosis. RIPK3 is a major necrotic protein in various types of neoplasms. In the process of eliminating and destroying tumour cells, the mechanisms and pathways of …
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The Paradoxical Roles of Cell Death Pathways in Immune Cells
… of programmed cell death via necrosis, known as necroptosis. I show that the cellular inhibitor of apoptosis (cIAP) proteins act to limit activation of key necroptosis proteins in macrophage cells. Furthermore, I show that necroptosis can be exploited by intracellular bacterial pathogens to …
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Thioredoxin-1 Inhibition Promotes MLKL Activation: Biochemical Insights Into a Suppressor of the Necroptotic Pathway
Necroptosis is an immunogenic caspase-independent cell death program. While mainly serving to defend against viral infection, dysregulated necroptotic signaling contributes to the pathology of a growing number of human diseases associated with inflammation, neurodegeneration, and ischemic injuries. …
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Discovery of Novel Mechanisms Regulating Cancer Extravasation in the Chorioallantoic Membrane Model
… not show activation of caspase-3. Activation of necroptosis, however, increased extracellular vesicle release and decreased cell extravasation and secondary colony formation. These results suggest that necroptosis may be targeted to induce extracellular vesicle release, decrease extravasation, …
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Investigating new roles of the ubiquitin proteasome system in cell death and innate immune signalling
… focused on a form of regulated cell death termed necroptosis, a type of cell death mediated by the receptor-interacting protein kinases (RIP). RIP kinases are known to interact with E3 ubiquitin ligases Pellino proteins. Pellino 1 has recently been described to target RIP kinases and regulate …
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Functional and Mechanistic Analysis of Protein Degradation by Human Cytomegalovirus to Uncover Viral Immune Evasion Mechanisms
… terminal effector of a form of cell death called necroptosis. Many herpesviruses suppress necroptotic signalling to evade cell death. However, the mechanism of HCMV-mediated inhibition of necroptosis has so far remained elusive. HCMV protein pUL36 was found to be necessary and sufficient for the …
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Influenza A Virus Induced Programmed Cell Death
… (e.g., apoptosis) or pro-inflammatory (e.g., necroptosis). In this dissertation, I outline experiments carried out to identify the role of pro-inflammatory programmed cell death in influenza A virus clearance and pathogenesis both in vitro and in vivo. My work outlines the role of necroptosis …
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Mode of Entry and Survival of Salmonella Enterica Serovar Typhimurium in Trophoblast Cells
… domain-like (MLKL), suggesting induction of the necroptosis pathway of cell death. Furthermore, specific inhibition of necroptosis rescued S.Tm-induced death of cTBCs. Finally, S.Tm infected trophoblast cells produced interleukin (IL)-10, and signal transducer and activator of transcription …
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Neuroprotective Functions of Docosahexaenoic Acid and Epidermal Fatty Acid Binding Protein
… not rescue neurons from PA-LTx but inhibition of necroptosis and promotion of autophagy do. DHA decreases the expression of HIF-1α and BNIP3 and rescues PA-induced cell death by inhibiting apoptosis and necroptosis. Besides DHA stimulates the mRNA expression, phosphorylation and conjugation of …
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Novel Protective Agents against Cerebral Ischemia/Reperfusion Injury.
… effects of HNG. Nec-1 is a specific inhibitor of necroptosis, a newly identified cell death, and was reported to reduce infarct volume even when it was administered at 6 h post-ischemia in a mouse stroke model. Interestingly, this small molecule protected against glutamate-induced oxidative …
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