Corrélation of Plasma Osteopontin Levels and 3D US Imaging with Tumor Response to Neoadjuvant Therapy

Locally advanced breast cancer (LABC) is an aggressive form of pre- metastatic breast cancer, with an expected five-year survival rate of 30-42%. The current standard of treatment is neoadjuvant therapy; however there is a limited ability to monitor tumor response to this treatment. This study looks at two innovative approaches to monitoring tumor response: measurement of plasma osteopontin (OPN) levels and three dimensional ultrasound imaging (3D US). Using our laboratory’s in house ELISA, we found that 39% of LABC patients had plasma OPN levels elevated above the normal healthy range of I23ng/ml (Bramwell,20o6). Over treatment this percent increased, such that at final cycle, 63% patients had elevated OPN levels. Plasma OPN levels at the final two cycles of treatment were significantly different from early levels (p

Name thesis:degree_name

M Sc

Discipline thesis:degree_discipline

Pathology

Year dc:date.issued

2008

Author dc:creator

• Caria, Laura B.R.

• Locally Advanced Breast Cancer
• Neoadjuvant Therapy
• Osteopontin
• Three Dimensional Ultrasound

Handle dc:identifier.uri

https://hdl.handle.net/20.500.14721/19214

OAI identifier oai:identifier

oai:uwo.scholaris.ca:20.500.14721/19214