Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 77 for “"Neoadjuvant"”.
-
Artificial intelligence in monitoring response to neoadjuvant therapy for breast cancer
Contains fulltext : 329216.pdf (Publisher’s version ) (Closed access)
-
Morphological quantitation software in breast MRI: application to neoadjuvant chemotherapy patients
The work in this thesis examines the use of texture analysis techniques and shape descriptors to analyse MR images of the breast and their application as a potential quantitative tool for prognostic indication.Textural information is undoubtedly very heavily used in a radiologist’s decision making …
-
Body mass index and response to neoadjuvant chemotherapy in Korean breast cancer
BACKGROUND AND OBJECTIVES: The relationship of neoadjuvant chemotherapy(NAC) and body mass index (BMI) in patients with breast cancer have been reported in many studies. According to many studies, poor prognosis is associated with obesity in western breast cancer patients, but not in oriental …
-
Ultrasound-based functionalized biopsy markers for lesion tracking through neoadjuvant systemic therapy
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-10-19 without embargo terms
-
Neoadjuvant endocrine therapy for estrogen receptor positive breast cancer in an African setting
… response rates for ER positive cancers on neoadjuvant endocrine therapy (NET), with lower toxicity compared to neoadjuvant chemotherapy (NCT). During the first wave of the COVID pandemic, clinician preference for NET increased significantly, buying time for hospital recovery before …
-
Predicting Response to Neoadjuvant Chemotherapy in Breast Cancer with Gene Expression and Computational Pathology
… for the removal of the tumour, which is known as neoadjuvant chemotherapy (NAT). It improves outcome for many patients, and their response to the treatment is prognostic for their overall outcome. However, not all patients who receive NAT respond to the treatment, and, as a result, many suffer …
-
The clonal architecture and tumour microenvironment of breast cancers are shaped by neoadjuvant chemotherapy
Neoadjuvant chemotherapy has become standard practice in patients with high-risk early breast cancer as it improves rates of breast conservation surgery and enables prediction of recurrence and survival by using response to treatment as a surrogate. Previous studies have focused on generating …
-
Corrélation of Plasma Osteopontin Levels and 3D US Imaging with Tumor Response to Neoadjuvant Therapy
… of 30-42%. The current standard of treatment is neoadjuvant therapy; however there is a limited ability to monitor tumor response to this treatment. This study looks at two innovative approaches to monitoring tumor response: measurement of plasma osteopontin (OPN) levels and three dimensional …
-
EGFR in Early Non-small Cell Lung Cancer: Tyrosine Kinase Inhibition in a Neoadjuvant Trial
… disease, we implemented a phase II trial of neoadjuvant gefitinib in clinical stage I NSCLC. Tumour shrinkage was seen in 43% of patients, with 11% achieving RECIST partial response (PR). Analysis of molecular markers showed EGFR TKD mutations in 17% of cases, being the only associated with …
-
Vergleich von Mikronukleus- und Chromosomenaberrationstechnik bei der Dokumentation zytogenetischer Schäden in neoadjuvant radio-chemotherapierten Rektumkarzinompatienten
… Patienten mit fortgeschrittenem Rektumkarzinom neoadjuvant radiochemotherapiert und entweder in Arm A mit 5-FU (1.+5. RT-Woche, 1000mg/m2/d) oder in Arm B mit 5-FU + Oxaliplatin (5-FU d 1-14 + d 22-35, 250mg/m2/d; Oxaliplatin d1,8,22,29, 50mg/m2/d) zusätzlich zur Bestrahlung mit 50,4Gy (1,8Gy/d) …
-
Analyzing the Effect of Neoadjuvant Stereotactic Ablative Body Radiotherapy on Pancreatic Tumour Perfusion Using Computed Tomography Perfusion
… tumour conditions for better surgical outcome, neoadjuvant chemotherapy is typically administered for BRPC patients. Unfortunately, due to the presence of a desmoplastic stroma, PDAC characteristically has a high tumour density, which can significantly limit tumour perfusion and restrict the …
-
Predictive factors of stable or progressive disease during anthracycline with/without taxane-based neoadjuvant chemotherapy in breast cancer
Purpose: Neoadjuvant chemotherapy (NAC) has been shown to effectively downstage locally advanced breast cancer; however, clinically, no response or a progression of the tumor can occur in some cases. Predictive factors of no response or progression are unknown compared to predictive factors of a …
-
The Performance of Circulating Biomarkers in the Prediction of Response to Neoadjuvant Therapy in Patients with Oesophago-gastric Cancer
… beyond 5 years after diagnosis. The addition of neoadjuvant therapy has been shown to increase survival in patients suitable for curative surgery. However, the additional gains are modest and the majority of patients do not respond sufficiently from therapy to gain any benefit. There is an urgent …
-
Comprehensive gene assessment of estrogen receptor positive breast cancers reveals that HER2 positive status plays an important role in resistance to neoadjuvant letrozole
… treatment decision making, who will respond to neoadjuvant letrozole therapy and who might benefit from the addition of combined HER2 targeted agents. Aims 1. To investigate which ER positive/ HER2 positive breast cancers respond to letrozole. 2. To compare the mechanisms of resistance to …
-
Comparison of two neoadjuvant chemotherapy in locally advanced breast cancer patients; Adriamycin and Docetaxel (AD) versus Adriamycin, Cyclophosphamide followed by Paclitaxel (AC-T)
BACKGROUND: Neoadjuvant chemotherapy (NAC) is one of the standard treatmentfor the patients with locally advanced breast cancer and is an option for the patients with operable breast cancer. Such as adjuvant chemotherapy in breast cancer, anthracycline and taxane-based regimens have been studied …
-
Imaging Markers for Staging of Rectal Carcinoma and Restaging after Neoadjuvant Therapy // Образни маркери при стадиране на ректален карцином и рестадиране след неоадювантна терапия
Предоперативното стадиране и проследяването на ректалния рак е от изключителна важност в модерната онкология. Ролята на образната диагностика е ключова. Целта на тази дисертация е да определи образните биомаркери за туморен отговор и регресия преди и след неоадювантна терапия. Образната диагностика …
-
The identification of biomarkers of chemotherapy resistance in breast cancer using comparative proteomics
… resistance is a major obstacle in effective neoadjuvant treatment for locally advanced breast cancer. The ability to predict tumour response would allow chemotherapy administration to be directed towards only those patients who would benefit, thus maximising treatment efficiency. This project …
-
Trends in Receipt and Timing of Multimodality Therapy in Early-Stage Pancreatic Cancer
… therapy, which consisted of both chemotherapy (neoadjuvant or adjuvant) and resection. Trends in the receipt and type of treatment were compared. Results Of 39,441 patients, 22.8 % of patients received no treatment, 18.5 % received chemotherapy only, 23.0 % underwent surgical resection alone, …
Page 1 of 4