University of Texas Health Science Center at Houston
The Role of an Ultraconserved Long Non-coding Rna in B-Cell Lymphomagenesis
Abstract
dc:description.abstract<p>Ultraconserved regions (UCRs) are genomic segments with perfect (100%) conservation between the orthologous regions of human, rat, and mouse genomes. UCRs can be transcribed into mono-exonic long non-coding RNAs (lncRNAs) known as transcribed ultraconserved regions (T-UCRs). These regions, despite lacking protein-coding potential, are increasingly recognized for their regulatory roles in gene expression, including the modulation of non-coding RNA (ncRNA) transcripts. NcRNAs play crucial roles in cellular processes, including oncogenic transformation, with emerging evidence revealing their ability to encode small peptides known as ncRNA-encoded peptides (ncPEPs). These peptides, originating from small open reading frames (smORFs), contribute to diverse cellular functions and are implicated in disease pathogenesis.</p>
Degree
thesis:*- Name thesis:degree_name
- Doctor of Philosophy (PhD)
- Level thesis:degree_level
- Dissertation (PhD)
- Year dc:date.available
- 2024
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Mohapatra, Swati
- Contributors dc:contributor
-
- George A. Calin, M.D., Ph.D.
- M. James You, M.D., Ph.D.
- Marina Konopleva, M.D., Ph.D.
Subjects
dc:subject × 10Identifiers
dc:identifier.*- Repository record dc:identifier
- https://digitalcommons.library.tmc.edu/utgsbs_dissertations/1379
- OAI identifier oai:identifier
- oai:digitalcommons.library.tmc.edu:utgsbs_dissertations-2436