Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 148 for “"Non-coding RNA"”.
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Role of long non-coding RNA in atherosclerosis
… needed to address this global epidemic. Long noncoding RNAs (lncRNAs) are an emergent class of molecules with diverse functional roles, widely expressed in human physiology and disease. Although some lncRNAs have already been identified in cardiovascular disease, their potential as novel …
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Non-Coding RNA Features Critical to the Replication of HIV-1
<p>The HIV-1 genome contains RNA sequences and structures that control many aspects of viral replication including, but not limited to transcription, splicing, nuclear export, translation, packaging and reverse transcription. Despite this extensive existing catalogue of RNA sequences that are …
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The role of long non-coding RNA LINC00673 in lung tumorigenesis
… networks involving multiple cellular species. Non-coding RNAs (ncRNAs) are a class of RNA molecules varying in size, biogenesis and mechanism of action that have established themselves as key regulators of cellular behaviour. This project explores the roles of long non-coding RNA (lncRNA) in …
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Systematic Identification of Independent Functional Non-coding RNA Genes in Oxytricha trifallax
Functional noncoding RNAs participate in a variety of biological processes: for example, modulating translation, catalyzing biochemical reactions, sensing environments etc. Independent of conventional approaches such as transcriptomics and computational comparative analysis, we took advantage of …
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ZFAS1: a long non-coding RNA with novel implications for ribosome function
Long non-coding RNAs (lncRNAs) are a class of pervasively transcribed non-coding transcripts, regulating gene expression at both the transcriptional and post transcriptional levels. Many lncRNAs exhibit altered expression in diseases processes. Breast cancers show deregulated expression of lncRNAs, …
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Non-coding RNA genes lost in Prader-Willi Syndrome stabilize target RNAs
… function. There is evidence that a cluster of non-coding RNA genes in the deleted region known as the SNORD116 genes may be the most critical genes deleted in Prader-Willi Syndrome. It is unknown what the SNORD116 genes do at the molecular level, but recent evidence suggests they regulate the …
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Rox1 function in dosage compensation: structural / functional analysis of a non-coding rna
<p>roX1 is a long non-coding RNA involved in the chromosome-wide gene regulation that occurs during dosage compensation in Drosophila. Dosage compensation in Drosophila melanogaster occurs by a global two-fold increase of transcription from the single male X chromosome. This essential process …
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In Vivo Functional Significance of Ccat2 Long Non-Coding Rna In Myelodysplastic Syndrome
<p>Long non-coding RNAs form the largest part of the mammalian non-coding transcriptome and control gene expression at various levels including chromatin modification, transcriptional and post-transcriptional processing. Although the underlying molecular mechanisms are not yet entirely understood, …
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The Role of an Ultraconserved Long Non-coding Rna in B-Cell Lymphomagenesis
… UCRs can be transcribed into mono-exonic long non-coding RNAs (lncRNAs) known as transcribed ultraconserved regions (T-UCRs). These regions, despite lacking protein-coding potential, are increasingly recognized for their regulatory roles in gene expression, including the modulation of …
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LONG NON-CODING RNA VENTHEART IS NECESSARY FOR VENTRICULAR CARDIOMYOCYTE SPECIFICATION AND FUNCTION
… regulated by various modulators including long non-coding RNAs (lncRNAs), which influence gene expression and cardiac cell fate. This thesis focuses on verifying and characterizing of one key lncRNA, VENTHEART (VHRT), which was identified as one of the top upregulated markers in cardiomyocyte …
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New Microfluidic Technologies for Studying Histone Modifications and Long Non-Coding RNA Bindings
… as DNA methylation, histone modification, and non-coding RNA interaction, play critical roles in cell differentiation and disease processes. The conventional approach requires the use of a few million or more cells as starting material. However, such quantity is not available when samples from …
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The Long Non-coding RNA Malat1 Regulates Inflammatory Cytokine Production in Chronic Diabetic Complications
… role of MALAT1, a highly conserved nuclear lncRNA, in chronic diabetic complications affecting the heart and kidneys, specifically with respect to inflammatory cytokine production. Endothelial cells, exposed to various glucose levels, and MALAT1 knockout mice and controls, with or without …
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REGULATION OF Fas-MEDIATED APOPTOSIS BY THE Fas ANTI-SENSE NON-CODING RNA "Saf"
… that can bind FasL and block apoptosis. Long noncoding RNAs (lncRNAs) are >200-nucleotide sequences that are important regulators of cellular programs. However, their role in erythropoiesis is just beginning to be appreciated with studies limited to murine systems. I studied the potential role …
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Role of Non-Coding RNA NC4 in MLL and CYP33 Mediated Regulation of HOXC8
… Homeo Domain (PHD) of MLL via its N terminal RNA Recognition Motif (RRM) such that its overexpression switches the function of transcriptional activator protein MLL towards transcriptional repressor. This repression is mediated in part by an enhanced recruitment of histone deacetylase 1 to MLL …
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Long non-coding RNA Hsr-omega provides scaffolding for the nuclear domain B-body
… We hypothesized that the B-body must contain an RNA scaffold because Bru association with B-bodies is RNase-sensitive. Using Immuno-FISH, we identified a lncRNA co-localizing with the B-body; this RNA is the <em>heat shock RNA omega</em> (<em>hsrω</em>). Next, we tested the requirement of protein …
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CODING E NON-CODING RNA COME BIOMARCATORI DI SEVERITA’ DI NAFLD E DI FIBROSI
La steatosi epatica non alcolica (Non-Alcoholic Fatty Liver Disease, NAFLD) è l’epatopatia cronica più comune nei paesi industrializzati con una prevalenza del 20-30% nella popolazione generale. La NAFLD comprende un vasto spettro di patologie epatiche e sebbene sia generalmente considerata una …
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Regulation of p21 Function by a Sense Long Non-Coding RNA Generated by Alternative Polyadenylation
… at different times of the DDR. Regulation of 3’ mRNA processing allows fast control of gene expression transcriptome wide as it is a ubiquitous co-transcriptional processing step. One powerful method widely used to control gene expression is alternative polyadenylation (APA). Approximately 70% of …
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Non-coding RNA networks regulating leaf vegetative desiccation tolerance in the resurrection plant Xerophyta humilis.
… is known with regards to the role of regulatory noncoding RNAs (ncRNAs). To investigate the presence and roles of possible ncRNA players, RNA-Seq was performed on desiccating Xerophyta humilis leaves and a bioinformatic pipeline assembled to identify the potential decoy lncRNAs and miRNAs …
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