Ultraconserved regions (UCRs) are genomic segments with perfect (100%) conservation between the orthologous regions of human, rat, and mouse genomes. UCRs can be transcribed into mono-exonic long non-coding RNAs (lncRNAs) known as transcribed ultraconserved regions (T-UCRs). These regions, despite lacking protein-coding potential, are increasingly recognized for their regulatory roles in gene expression, including the modulation of non-coding RNA (ncRNA) transcripts. NcRNAs play crucial roles in cellular processes, including oncogenic transformation, with emerging evidence revealing their ability to encode small peptides known as ncRNA-encoded peptides (ncPEPs). These peptides, originating from small open reading frames (smORFs), contribute to diverse cellular functions and are implicated in disease pathogenesis.
","abstract_html":"<p>Ultraconserved regions (UCRs) are genomic segments with perfect (100%) conservation between the orthologous regions of human, rat, and mouse genomes. UCRs can be transcribed into mono-exonic long non-coding RNAs (lncRNAs) known as transcribed ultraconserved regions (T-UCRs). These regions, despite lacking protein-coding potential, are increasingly recognized for their regulatory roles in gene expression, including the modulation of non-coding RNA (ncRNA) transcripts. NcRNAs play crucial roles in cellular processes, including oncogenic transformation, with emerging evidence revealing their ability to encode small peptides known as ncRNA-encoded peptides (ncPEPs). These peptides, originating from small open reading frames (smORFs), contribute to diverse cellular functions and are implicated in disease pathogenesis.</p>","abstract_has_math":false,"creators":["Mohapatra, Swati"],"institution":null,"degree_name":"Doctor of Philosophy (PhD)","degree_level":"Dissertation (PhD)","degree_discipline":null,"degree_department":null,"school":null,"contributors":["George A. Calin, M.D., Ph.D.","M. James You, M.D., Ph.D.","Marina Konopleva, M.D., Ph.D."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2024,"date_issued":"2024-08-01T07:00:00Z","date_published":"2024-08-01T07:00:00Z","updated_at":"2026-07-24T05:49:08Z","subjects":["Functional Peptides","Ultraconserved Regions","CRISPR-Cas9","Chronic Lymphocytic Leukemia","Adaptive Immunity","B-cell Development","Biology","Genetics and Genomics","Immunology and Infectious Disease","Medical Sciences"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/1379","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["George A. Calin, M.D., Ph.D.","M. James You, M.D., Ph.D.","Marina Konopleva, M.D., Ph.D."]},{"key":"dc:creator","label":"Author","values":["Mohapatra, Swati"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.available","label":"Dc Date Available","values":["2025-07-25T07:00:00Z"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation (PhD)"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Doctor of Philosophy (PhD)"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Functional Peptides","Ultraconserved Regions","CRISPR-Cas9","Chronic Lymphocytic Leukemia","Adaptive Immunity","B-cell Development","Biology","Genetics and Genomics","Immunology and Infectious Disease","Medical Sciences"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://digitalcommons.library.tmc.edu/utgsbs_dissertations/1379"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Ultraconserved regions (UCRs) are genomic segments with perfect (100%) conservation between the orthologous regions of human, rat, and mouse genomes. UCRs can be transcribed into mono-exonic long non-coding RNAs (lncRNAs) known as transcribed ultraconserved regions (T-UCRs). These regions, despite lacking protein-coding potential, are increasingly recognized for their regulatory roles in gene expression, including the modulation of non-coding RNA (ncRNA) transcripts. NcRNAs play crucial roles in cellular processes, including oncogenic transformation, with emerging evidence revealing their ability to encode small peptides known as ncRNA-encoded peptides (ncPEPs). These peptides, originating from small open reading frames (smORFs), contribute to diverse cellular functions and are implicated in disease pathogenesis.
"]},{"key":"dc:title","label":"Title","values":["The Role of an Ultraconserved Long Non-coding Rna in B-Cell Lymphomagenesis"]}]}],"canonical_facts":{"dc:contributor":["George A. Calin, M.D., Ph.D.","M. James You, M.D., Ph.D.","Marina Konopleva, M.D., Ph.D."],"dc:creator":["Mohapatra, Swati"],"dc:date.available":["2025-07-25T07:00:00Z"],"dc:description.abstract":["Ultraconserved regions (UCRs) are genomic segments with perfect (100%) conservation between the orthologous regions of human, rat, and mouse genomes. UCRs can be transcribed into mono-exonic long non-coding RNAs (lncRNAs) known as transcribed ultraconserved regions (T-UCRs). These regions, despite lacking protein-coding potential, are increasingly recognized for their regulatory roles in gene expression, including the modulation of non-coding RNA (ncRNA) transcripts. NcRNAs play crucial roles in cellular processes, including oncogenic transformation, with emerging evidence revealing their ability to encode small peptides known as ncRNA-encoded peptides (ncPEPs). These peptides, originating from small open reading frames (smORFs), contribute to diverse cellular functions and are implicated in disease pathogenesis.
"],"dc:identifier":["https://digitalcommons.library.tmc.edu/utgsbs_dissertations/1379"],"dc:subject":["Functional Peptides","Ultraconserved Regions","CRISPR-Cas9","Chronic Lymphocytic Leukemia","Adaptive Immunity","B-cell Development","Biology","Genetics and Genomics","Immunology and Infectious Disease","Medical Sciences"],"dc:title":["The Role of an Ultraconserved Long Non-coding Rna in B-Cell Lymphomagenesis"],"thesis:degree_level":["Dissertation (PhD)"],"thesis:degree_name":["Doctor of Philosophy (PhD)"]},"updated_at":"2026-07-24T05:49:08Z"}