Decoding The Tumor and Immune Microenvironment In Pdac and Breast Cancer By Single Cell Sequencing.

<p>This work utilizes single cell RNA sequencing to identify transcriptional populations and gene changes for the purpose of immune-related cancer therapies. First we have characterized the T cell populations of the normal and malignant human pancreas. Furthermore, we utilized single cell TCR sequencing to track transcriptional states of T cell clones from human PDACs into a T cell culture product for adoptive cell therapy. Second, we examined the potential role of radiotherapy in inducing an immune response in hormone receptor positive breast tumors.</p>

Name thesis:degree_name

Doctor of Philosophy (PhD)

Level thesis:degree_level

Dissertation (PhD)

Year dc:date.available

2022

Authors dc:creator

• Schalck, Aislyn
• <p>0000-0002-4020-1822</p>

Contributors dc:contributor

• Nick Navin
• Ken Chen
• Simona Shaitelman

• single cell
• breast cancer
• genomics
• PDAC
• cell therapy
• radiotherapy

Repository record dc:identifier

https://digitalcommons.library.tmc.edu/utgsbs_dissertations/1197

OAI identifier oai:identifier

oai:digitalcommons.library.tmc.edu:utgsbs_dissertations-2254