Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 1445 for “"genomics"”.
-
Genomics of Butterflies
… us to study biological questions by comparative genomics of a large group of organisms. We developed methods to sequence and comparatively analyze genomes of butterflies and address general questions of molecular evolution and connection between genotype and phenotype. First, we study mimetic …
-
Algorithms in comparative genomics
The field of comparative genomics is abundant with problems of interest to computer scientists. In this thesis, the author presents solutions to three contemporary problems: obtaining better alignments for phylogeny reconstruction, identifying related RNA sequences in genomes, and ranking Single …
-
Comparative genomics of Bifidobacteria
Chapter 2 of this thesis describes the sequence analysis of 14 bifidobacterial genomes from various species of the genus Bifidobacterium, and the determination of their open pan-genome trend. This analysis first determined the total number of genes to be considered as the reservoir of functions …
-
High-Performance Computational Genomics
… domain-specific language for bioinformatics and genomics that combines the power and usability of high-level languages like Python with the performance of low-level languages like C or C++. Seq allows for shorter, simpler code, is readily usable by a novice programmer, and obtains significant …
-
Population Genomics of Polistes Wasps
The molecular mechanisms influencing the evolution of social behaviour in insects are of great interest and have been the focus of many recent studies. Chapter one of this thesis reviews several major hypotheses regarding the evolution of sociality. Chapter two outlines the methodological steps …
-
Multiscale glass lizard conservation genomics
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2027-08-01
-
Functional genomics of developmental disorders
DNA methylation, or the epigenetic modification of primarily cytosine bases within DNA to 5-methylcytosine through the addition of a methyl group, is an epigenetic mark with a variety of biological and cellular roles. Genetic and environmental influences can perturb DNA methylation patterns in …
-
Mammalian comparative genomics and epigenomics
The human genome sequence can be thought of as an instruction manual for our species, written and rewritten over more than a billion of years of evolution. Taking a complete inventory of our genome, dissecting its genes and their functional components, and elucidating how these genes are …
-
Two Problems in Computational Genomics
… two novel problems in the field of computational genomics. The first is whole genome alignment and the second is inferring horizontal gene transfer using posets. We define these two problems and present algorithmic approaches for solving them. For the whole genome alignment, we define alignment …
-
Comparative genomics of early animal evolution
The explosion of genomics permits investigations into the origin and early evolution of the Metazoa at the molecular level. In this thesis, I am particularly interested in investigating the molecular foundation of the animal senses (i.e. how animals perceive their world). To understand the …
-
Genomics, Metagenomics and Phylogenomics of Cyanobacteria
This PhD thesis concerns the genomics, metagenomics and phylogenomics of Cyanobacteria. It is composed of five main parts, of which four are result manuscripts. In the first part (i.e., Introduction), I review a decade of cyanobacterial phylogeny and molecular dating. I show that, in spite of a …
-
Detection of Bacterial Retroelements Using Genomics
<p>The reverse flow of genetic information can occur when a special DNA polymerase called Reverse Transcriptase (RT) copies the genetic information in an RNA molecule back into a complementary DNA. One type of RT encoding gene found in bacteria is called a retron element. Recent bacterial genome …
-
Luminescent Systems for Genomics and Proteomics
… in the fields of biology, proteomics and genomics. Different aspects and problems were investigated, requiring different strategies and approaches. The whole work was thus divided into separate chapters, each based on the study of one specific aspect of luminescence: Chemiluminescence, …
-
Speciation Genomics in Australian Meliphagoid Birds
… gerygones, and allies. Using a comparative genomics approach, I tested hypotheses on how genome divergence and gene flow changes as populations diverge and proceed through the speciation process. The first chapter sets the stage for analyzing this new system. I characterized variation in …
-
Speciation Genomics in Australian Meliphagoid Birds
… gerygones, and allies. Using a comparative genomics approach, I tested hypotheses on how genome divergence and gene flow changes as populations diverge and proceed through the speciation process. The first chapter sets the stage for analyzing this new system. I characterized variation in …
-
Functional genomics of plant compensatory responses
Numerous studies have shown that some plant genotypes can compensate for tissues lost with little or no decrement in fitness relative to those that are undamaged (see Stowe et al. 2000 for a review); such plants are termed as tolerant. This trait motivated many empirical studies demonstrating that …
-
Algorithms for infection and cancer genomics
The student, Palash Sashittal, submitted this Thesis for approval on 2021-07-19 at 11:33.
-
Genomics and epigenomics using 2D nanopores
DNA methylation is an epigenetic modification caused by the addition of a methyl group to DNA and heavily involved in gene expression and regulation, thereby critical to the progression of diseases such as cancer. In this work we show that detection and localization of DNA methylation can be …
-
Computational methods for personalized cancer genomics
In recent years, cancer treatment strategies have moved towards personalized approaches, specifically tailoring cancer treatments on a single-patient basis using molecular profiles from the patients’ tumor genomes. Knowledge of a patient’s molecular profile can be used to 1) identify the disease …
Page 1 of 73