This work utilizes single cell RNA sequencing to identify transcriptional populations and gene changes for the purpose of immune-related cancer therapies. First we have characterized the T cell populations of the normal and malignant human pancreas. Furthermore, we utilized single cell TCR sequencing to track transcriptional states of T cell clones from human PDACs into a T cell culture product for adoptive cell therapy. Second, we examined the potential role of radiotherapy in inducing an immune response in hormone receptor positive breast tumors.
","abstract_html":"<p>This work utilizes single cell RNA sequencing to identify transcriptional populations and gene changes for the purpose of immune-related cancer therapies. First we have characterized the T cell populations of the normal and malignant human pancreas. Furthermore, we utilized single cell TCR sequencing to track transcriptional states of T cell clones from human PDACs into a T cell culture product for adoptive cell therapy. Second, we examined the potential role of radiotherapy in inducing an immune response in hormone receptor positive breast tumors.</p>","abstract_has_math":false,"creators":["Schalck, Aislyn","0000-0002-4020-1822
"],"institution":null,"degree_name":"Doctor of Philosophy (PhD)","degree_level":"Dissertation (PhD)","degree_discipline":null,"degree_department":null,"school":null,"contributors":["Nick Navin","Ken Chen","Simona Shaitelman"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2022,"date_issued":"2022-08-01T07:00:00Z","date_published":"2022-08-01T07:00:00Z","updated_at":"2026-07-24T05:49:54Z","subjects":["single cell","breast cancer","genomics","PDAC","cell therapy","radiotherapy"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://digitalcommons.library.tmc.edu/utgsbs_dissertations/1197","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Nick Navin","Ken Chen","Simona Shaitelman"]},{"key":"dc:creator","label":"Author","values":["Schalck, Aislyn","0000-0002-4020-1822
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"]},{"key":"dc:title","label":"Title","values":["Decoding The Tumor and Immune Microenvironment In Pdac and Breast Cancer By Single Cell Sequencing."]}]}],"canonical_facts":{"dc:contributor":["Nick Navin","Ken Chen","Simona Shaitelman"],"dc:creator":["Schalck, Aislyn","0000-0002-4020-1822
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"],"dc:identifier":["https://digitalcommons.library.tmc.edu/utgsbs_dissertations/1197"],"dc:subject":["single cell","breast cancer","genomics","PDAC","cell therapy","radiotherapy"],"dc:title":["Decoding The Tumor and Immune Microenvironment In Pdac and Breast Cancer By Single Cell Sequencing."],"thesis:degree_level":["Dissertation (PhD)"],"thesis:degree_name":["Doctor of Philosophy (PhD)"]},"updated_at":"2026-07-24T05:49:54Z"}