Changes In The Testes Following Spinal Cord Injury and The Attenuating Effects of Licofelone

<p>Spinal cord injury is a devastating disease that researchers have had very limited success in treating. In addition to interrupted innervation, spinal cord injury causes pathologic changes in a multitude of organ systems. Male infertility is one such complication that is particularly devastating because the patient population is predominantly young men. Our lab has previously shown that the blood testis barrier breaks down after spinal cord injury. This dissertation shows the local metabolomic and mRNA changes that spinal cord injury causes within the testes using a Sprague Dawley rat model, including the elevation in eicosanoids, increased oxidative stress, chronically elevated unconjugated bile acids, altered immune cell populations, acutely decreased testosterone production, and acute elevations in lysolipids. In addition, we show promising and long lasting attenuation of many of these changes with early treatment with licofelone, a dual cox/lox inhibitor, including attenuation of bile acid levels, lysolipids, inflammation, and oxidative stress. This indicates a promising avenue for future research into alleviating this symptom of a devastating injury.</p>

Name thesis:degree_name

Doctor of Philosophy (PhD)

Level thesis:degree_level

Dissertation (PhD)

Year dc:date.available

2018

Authors dc:creator

• Fortune, Ryan
• <p>0000-0002-9548-9288</p>

Contributors dc:contributor

• David Loose, Ph.D.
• Ruth Heidelberger, M.D., Ph.D.
• Darren Boehning, Ph.D.

• Spinal Cord Injury
• male infertility
• testes
• inflammation
• oxidative stress
• metabolomics
• mRNA
• rat model
• Disease Modeling
• Male Urogenital Diseases
• Medicine and Health Sciences
• Nervous System Diseases

Repository record dc:identifier

https://digitalcommons.library.tmc.edu/utgsbs_dissertations/878

OAI identifier oai:identifier

oai:digitalcommons.library.tmc.edu:utgsbs_dissertations-1923