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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 3256 for “"mRNA"”.

  1. Nonsense-mediated mRNA reduction and pre-mRNA processing in drosophila

    Brogna, SaverioThe Open University2000

    … mutation causes a reduction in the level of the mRNA of the corresponding gene. The reduction is not, contrary to initial expectations, due to a passive mechanism by which non translated mRNAs are degraded; rather it is a active process in which active translation, cis-acting sequences and …

    the-open-u Repository record

  2. Functions of Deadenylation Factors In Mrna Decay and Mrna Processing Body Formation

    Zheng, Dinghai2010

    … because deadenylation not only leads to mRNA translational inhibition but also is the first step of major mRNA degradation. Translationally inhibited mRNAs can be stored and/or degraded in dynamic cytoplasmic foci termed mRNA processing bodies, or P bodies, which are conserved in …

    uthsc Repository record

  3. Theory of mRNA degradation

    Deneke, CarlusUniversität Potsdam

    … concerns the regulation of the stability of mRNAs. All organisms have evolved diverse and powerful mechanisms to achieve this. In order to better comprehend the regulation in living cells, biochemists have studied specific degradation mechanisms in detail. In addition to that, modern …

    potsdam-diss Repository record

  4. Investigating Mechanisms of Nuclear mRNA Export

    Lee, Eliza S2021

    … implications for nuclear export and retention of mRNAs. This division ensures that only correctly processed mRNAs are exported to the cytoplasm to be translated into proteins, while misprocessed and aberrant transcripts are retained in the nucleus to be degraded by various nuclear surveillance …

    toronto-retro Repository record

  5. Statistical Analysis of mRNA-miRNA Interaction

    Bhattacharya, Surajit2013

    gmu

  6. mRNA localization in Caenorhabditis elegans embryogenesis

    Parker, Dylan M., author, Osborne Nishimura, Erin, advisor, Ben-Hur, Asa, committee member, Montgomery, Tai, committee member, Stasevich, Tim, committee member, Santangelo, Tom, committee memberColorado State University. Libraries2021

    … output, post-transcriptional regulation of mRNA is essential for life. As a result, many mechanisms underlying post-transcriptional regulation are highly conserved across the kingdoms of life. As the spatial resolution of microscopy and sequencing assays has increased, mRNA localization has …

    colostate Repository record

  7. Investigating Hfq-Mrna Interactions In Bacteria

    Faner, Martha Audra2013

    … the stability and/or translation of their target mRNAs through complementary base-pairing. The base-pairing interaction is not perfect and requires the action of an RNA binding protein, Hfq. Hfq facilitates these RNA-RNA interactions by stabilizing duplex formation, aiding in structural …

    wayne-thes Repository record

  8. Interrogating Dux4 Mrna 3′ End Processing

    Peart, Natoya J2017

    … transcription of a polyadenylated Dux4 mRNA from the terminal D4Z4 repeat. Dux4 is anemically expressed in patient somatic cells, but contributes to FSHD pathology due to Dux4-dependent cellular reprogramming.</p> <p>We aim to understand what regulatory elements facilitate the cleavage …

    uthsc Repository record

  9. Analysis of AUF1 targeted mRNA sequences

    Lu, Jiebo

    … binding protein, plays an important role in mRNA decay. To identify the mRNAs that interact with AUF 1, mRNA derived from a human cardiac cDNA expression library was purified by AUF 1 affinity chromatography and cloned following RT-PCR. 261 sequences were obtained. The sequences were searched …

    njit Repository record

  10. Bioinformatics study of mammalian MRNA polydenylation

    Zhang, Haibo

    … cells, which have influences on many aspects of mRNA metabolism. Several human diseases have been shown to associate with abnormal polyadenylation, highlighting the importance of this process. The availability of the complete sequence of human and mouse genomes, together with their gene …

    njit Repository record

  11. SR proteins in microRNA/mRNA biogenesis

    Wu, Han2011

    … constitutive and alternative splicing of pre-mRNAs. Despite years of studies, several big questions still remain: how the expression levels of SR proteins are regulated; what are the underlying mechanisms responsible for SR proteins-mediated gene regulation; what are the physiological targets …

    duke Repository record

  12. Charakterisierung der dendritischen Lokalisierung der Shank1-mRNA

    Segger-Junius, MailinUniversität Oldenburg

    … wurden in Dendriten inzwischen auch mRNAs identifiziert. Zu diesen gehört die mRNA eines der wesentlichen Strukturproteine der postsynaptischen Dichte, Shank1. In dieser Dissertation wurde die dendritische Lokalisierung der Shank1-mRNA untersucht und das cis-agierende dendritische …

    oldenburg Repository record

  13. REGULACE PRE-mRNA SESTŘIHU V BUNĚČNÉM JÁDŘE

    Tománková, TerezaUniverzita Karlova, Přírodovědecká fakulta2006

    charles-prague Repository record

  14. Quantitative mRNA detection with advanced nonlinear microscopy

    Liu, Jing

    … information on quantity and localization of key mRNA transcripts in single-cell level are critical to the assessment of cancer risk, therapy efficacy, and effective prevention strategies. While current techniques are not capable to visualize single mRNA transcript beyond the diffraction limit. In …

    purdue-thes Repository record

  15. Regulation of yeast development by mRNA methylation

    Agarwala, Sudeep DMassachusetts Institute of Technology2012

    The internal methylation of mRNA post-transcriptionally is an essential component of the mRNA editing machinery in virtually every eukaryotic system. Despite this ubiquity, little is known about the relevance, consequences or machinery involved in this process. The recent demonstration of this …

    mit Repository record

  16. The evolution of mRNA splicing in mammals

    Merkin, Jason JayMassachusetts Institute of Technology2014

    In this thesis, I describe investigations into the evolution of splicing in mammals. I first investigate a small class of alternative splicing events, tandem splice sites, and show how they are used to introduce and remove coding sequence in a species-specific manner. I then describe the generation …

    mit Repository record

  17. SOMATIC SIGNALS REGULATING MRNA TRANSLATION IN MAMMALIAN OOCYTE.

    LADRON DE GUEVARA, MAGDALENAUniversità degli Studi di Milano2024

    … mechanisms on a background of repressed mRNA transcription. However, a comprehensive understanding of this regulation in higher-order mammals has been limited by challenges in isolating polysome-associated mRNAs. This study aims to shed light on these processes and how they can be …

    milano Repository record

  18. Functions of Dcp2 and Ski7 In Mrna Degradation

    Kim, Minseon, van Hoof, Ambro, <p>0000-0001-5299-0008</p>2022

    … fidelity. This is partially achieved by mRNA decay. When no longer required, mRNA is degraded by two alternative pathways. The decapping enzyme Dcp2 removes the 5` <sup>m7</sup>G cap of mRNAs, allowing Xrn1 to degrade the mRNA from the 5` end. Alternatively, mRNA is degraded from the 3` …

    uthsc Repository record

  19. Mechanistic Studies Of Trypanosoma Brucei Mitochondrial Mrna Editing.

    Harris, Michael Edmund

    uab Repository record

  20. Molekulare Analyse der mRNA-Expression von Plasma-Prokallikrein

    Neth, PeterLudwig-Maximilians-Universität

    … Rolle. Neuere Arbeiten haben gezeigt, dass PPKmRNA auch außerhalb der Leber exprimiert wird. Daraus ist zu schließen, dass dort ebenfalls PPK-Protein gebildet wird und dass diesem extrahepatischen, gewebeständigen PPK bzw. PK spezielle lokale Funktionen zukommen. Dieser Befund bildet die …

    lmu-germany Repository record

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