Dissecting The Molecular Mechanism of Early Tumor Dissemination In Non-Small Cell Lung Cancer

<p>Lung cancer is the most common cause of cancer related death in the United States and worldwide. It has been shown that 30%-55% of patients with early stages of non-small cell lung cancer (NSCLC) developed and died of recurrence after curative resection, suggesting that tumor cell dissemination occurred early in those patients before surgery. However, molecular evidence, underline mechanisms and risk factors for the NSCLC relapse remain largely unknown. Addressing these questions will be critical for the development of strategies to stratify the risk of recurrence and approaches to reduce these risks. My thesis focused on dissecting the molecular basis of early tumor cell dissemination (ETCD) using mouse models of NSCLC. First, we established and characterized a new mouse model of NSCLC using lung specific activation of an epidermal growth factor receptor (EGFR) mutant form in combination with loss of p53. Using this model and an oncogene Kras–driven lung cancer model, we identified that the combination of inflammation and stress is a major contributor to induce ETCD. A small number of the early disseminated tumor cells (</p>

Name thesis:degree_name

Doctor of Philosophy (PhD)

Level thesis:degree_level

Dissertation (PhD)

Year dc:date.available

2018

Authors dc:creator

• Liu, Xingtong
• <p>https://orcid.org/0000-0002-1161-7976</p>

Contributors dc:contributor

• Xiangwei Wu
• Anil K. Sood
• Samir M. Hanash

• NSCLC
• CTC
• early cancer dissemination
• inflammation
• stress
• Cancer Biology
• Medicine and Health Sciences

Repository record dc:identifier

https://digitalcommons.library.tmc.edu/utgsbs_dissertations/870

OAI identifier oai:identifier

oai:digitalcommons.library.tmc.edu:utgsbs_dissertations-1915