Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"EGFR-mutant"”.
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The Role of Protocadherin 7 in Lung Adenocarcinoma
… led to a significant decrease in phospho-EGFR, leading us to hypothesize that PCDH7 may directly interact with EGFR and modulate signaling through this receptor. We demonstrate that PCDH7 interacts with EGFR in a phospho-dependent manner, and that loss of this interaction in PCDH7 …
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The Role of Protocadherin 7 in Lung Adenocarcinoma
… led to a significant decrease in phospho-EGFR, leading us to hypothesize that PCDH7 may directly interact with EGFR and modulate signaling through this receptor. We demonstrate that PCDH7 interacts with EGFR in a phospho-dependent manner, and that loss of this interaction in PCDH7 …
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Methylation of Egfr By Arginine Methyltransferase Prmt1 Enhances Egfr Signaling and Cetuximab Resistance
… of epidermal growth factor receptor (EGFR) intracellular domain are well known regulators of EGFR functions whereas those of its extracellular domain remain relatively unexplored. Here, we report that methylation at R198 and R200 of EGFR extracellular domain by protein arginine …
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Dissecting The Molecular Mechanism of Early Tumor Dissemination In Non-Small Cell Lung Cancer
… of an epidermal growth factor receptor (EGFR) mutant form in combination with loss of p53. Using this model and an oncogene Kras–driven lung cancer model, we identified that the combination of inflammation and stress is a major contributor to induce ETCD. A small number of the early …
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Uncovering Molecular Targets to Overcome Immunosuppression In Non-Small Cell Lung Cancer With Acquired Tki Resistance
… such as epidermal-like growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) or monoclonal antibodies targeting vascular endothelial growth factor (VEGF/R), can effectively inhibit upregulated signaling pathways driving tumorigenesis in NSCLC and many other cancers. Unfortunately, …
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EGFR deficiency results in defective hair follicle cycling, resistance to chemotherapy-induced alopecia, and cutaneous inflammation
… patients with epidermal growth factor receptor (EGFR) inhibitors causes perifollicular inflammation in the skin. Mouse models with EGFR deficiency predicted this folliculitis and revealed that abrogation of EGFR disrupts hair follicle cycling. Hair follicles transition between the anagen growth …
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Defining The Role of Egfr Acetylation In Cellular Processes: Clinical Implications
<p> Epidermal growth factor receptor (EGFR) is a cell membrane tyrosine kinase receptor and plays a pivotal role in regulating cell growth, differentiation, cell cycle, and tumorigenesis. Deregulation of EGFR causes many diseases including cancers. Intensive investigation of EGFR alteration in …
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Negative feedback regulation as a means to constrain the oncogenic potential of mutant Egfr in NSCLC
The discovery of EGFR kinase domain mutations in NSCLC patients who responded to tyrosine kinase inhibitors (TKIs) represented the first example of a targeted therapy for lung cancer. The dependence of these human tumors on sustained mutant receptor expression for survival, together with the …