Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 156 for “"NSCLC"”.
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Radiomics of Nsclc: Quantitative Ct Image Feature Characterization and Tumor Shrinkage Prediction
… image features. For non-small cell lung cancer (NSCLC) patients, radiomics can be applied to standard of care computed tomography (CT) images to improve tumor diagnosis, staging, and response assessment.</p> <p>The first objective of this work was to show that CT image features extracted from …
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Assessing the temporal role of miR-200 loss in murine models of NSCLC
… United States, with non-small cell lung cancer (NSCLC) making up a majority of new diagnoses. Metastasis is the big killer in NSCLC and is driven by epithelial-mesenchymal transition (EMT) and immune evasion. The microRNA 200 family is a master regulator of EMT and is implicated in immune …
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TRATTAMENTO DEL NSCLC EGFR-MUTATO LOCALMENTE AVANZATO MEDIANTE ASSOCIAZIONE DI ERLOTINIB E RADIOTERAPIA
… pazienti affetti da carcinoma del polmone NSCLC localmente avanzato, ad istologia non squamosa ed esprimenti mutazione del gene per l Epidermal Growth Factor Receptor (EGFR) e di candidarli ad un trattamento combinato di radioterapia e targeted therapy. Razionale e Background: i recenti …
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Investigating Therapeutic Strategies to Target Metabolic Vulnerabilities of Nsclc Tumors With Mutant Keap1 Gene
… of NRF2/SLC7A11 mediated glucose dependency to NSCLC cells carrying mutated KEAP1. I show that KEAP1 mutation/deficiency leads to constitutive activation of NRF2 and aberrant expression of NRF2 target cystine/glutamate antiporter SLC7A11. I further show a toxic accumulation of disulfide …
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Improving Dose-Response Correlations For Locally Advanced Nsclc Patients Treated With Imrt Or Pspt
… for locally advanced non-small cell lung cancer (NSCLC) is concurrent chemo-radiotherapy. Despite recent advancements in radiation delivery methods, the median survival time of NSCLC patients remains below 28 months. Higher tumor dose has been found to increase survival but also a higher rate of …
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Heterogeneity in Human NSCLC Tumor Glucose Metabolism: On the Origins and Role of Pyruvate Metabolism
Pages 9-96 are misnumbered as pages 10-97.
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Negative feedback regulation as a means to constrain the oncogenic potential of mutant Egfr in NSCLC
The discovery of EGFR kinase domain mutations in NSCLC patients who responded to tyrosine kinase inhibitors (TKIs) represented the first example of a targeted therapy for lung cancer. The dependence of these human tumors on sustained mutant receptor expression for survival, together with the …
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AXL Targeting Restores PD-1 Blockade Sensitivity of STK11/LKB1 Mutant NSCLC Through Expansion of TCF1+ CD8 T Cells
… in STK11/LKB1 in non-small cell lung cancer (NSCLC) are associated with poor patient responses to immune checkpoint blockade (ICB) for unknown reasons. We found that introduction of a Stk11/Lkb1 (L) mutation into murine lung adenocarcinomas driven by mutant Kras and Trp53 (KP) resulted in an …
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Mitomycin/Cisplatin oder Mitomycin/Vinorelbin und Erythropoetin als Therapie bei vorbehandelten Patienten mit Rezidiv eines NSCLC innerhalb des Bestrahlungsfeldes
… nicht-kleinzelligen Lungenkarzinomen (NSCLC) der Stadien IIIA und IIIB besteht aus einer definitiven Radiochemotherapie, die Chemotherapie ist in der Regel platinhaltig. Die Überlebenszeiten sind allerdings niedrig und bis zu 71% der Patienten entwickeln ein Rezidiv, das im ehemaligen …
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Investigation of Quatitative Image Features From Pretreatment Ct and Fdg-Pet Scans In Stage Iii Nsclc Patients Undergoing Defintive Radiation Therapy
<p>The purpose of this work was to determine if quantitative image features (QIFs) extracted from computed tomography (CT) and flourodeoxyglucose (FDG) positron emission tomography (PET) could provide prognostic information to improve outcome models. Our goal for this work was to determine if it …
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The Role of RUVBL1/RUVBL2 and Their Potential as Therapeutic Targets in Non-Small Cell Lung Cancer
… are a type known as non-small cell lung cancer (NSCLC), and despite numerous advances in the treatment of NSCLC, only 18% of all NSCLC patients live 5 years after their initial diagnosis. To identify new therapeutic targets in NSCLC, we performed a viability-based RNA interference (RNAi) screen …
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Cost-utility analysis of EML4-ALK fusion testing followed by treatment with crizotinib in patients with Non-Small Cell Lung Cancer (NSCLC)
Objective NSCLC is the most common type of lung cancer and accounts for about 85% of all lung cancers. Currently a majority of patients with NSCLC are treated with surgical resection and/or cytotoxic drugs. Chemotherapy has resulted in a modest increase (median survival of 8 months with …
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Uncovering Molecular Targets to Overcome Immunosuppression In Non-Small Cell Lung Cancer With Acquired Tki Resistance
<p>Non-small cell lung cancer (NSCLC) remains the leading cause of cancer-related deaths worldwide. Targeted therapeutic agents, such as epidermal-like growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) or monoclonal antibodies targeting vascular endothelial growth factor (VEGF/R), can …
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Epithelial to Mesenchymal Transition As A Predictor of Response to Polo-Like Kinase 1 Inhibition-Induced Apoptosis In Non-Small Cell Lung Carcinoma
<p>Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide. Outcomes are poor for patients with recurrent, advanced or metastatic NSCLC. Polo-like kinase 1 (PLK1), involved in the regulation of mitotic processes and the response to DNA damage, is overexpressed in …
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Retrospektiver Vergleich der Behandlungsergebnisse konventioneller Resektionstechniken des NSCLC im Stadium Ia/Ib mit Lasersegmentresektionen unter Anwendung eines neu entwickelten 1318nm Nd:YAG-Lasers
Unter den bösartigen Tumoren hat das Bronchialkarzinom wohl die dramatischste Entwicklung genommen. Die Inzidenz und Mortalität ist in den letzten 15-20 Jahren bei Männern zwar leicht rückläufig, für Frauen ist jedoch ein entgegen gesetzter Trend zu erkennen. Dies wird in erster Linie auf die …
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