Bacterial Challenge in Lumbricus Terrestris: A Terrestrial Invertebrate Immunotoxicity Model.

A bacterial challenge assay was developed utilizing the earthworm, Lumbricus terrestris, in order to assess potential immunotoxic effects from exposure to specific polychlorinated biphenyl congeners. Earthworms were inoculated with Aeromonous hydrophila, establishing a 10-day LD50. In vitro assays for effects of PCBs on phagocytosis agreed with mammalian studies, demonstrating potent suppression of phagocytosis by the non-coplanar PCB congener 138 and no suppression by the coplanar congener 126. However, when the effects of the two PCB congeners were evaluated for suppression of resistance to a whole animal infection challenge assay, coplanar PCB 126 decreased the ability of L. terrestris to withstand infection while non-coplanar PCB 138 did not.

Grantor dc:publisher

University of North Texas

Year dc:date

2007

Author dc:creator

• McDonald, Jennifer C.

Contributors dc:contributor

• Venables, Barney J.
• Fitzpatrick, Lloyd
• Goven, Arthur J.

• Immunotoxicity
• lumbricus terrestris
• PCBs
• suppression
• Earthworms -- Immunology.
• Immunotoxicology.
• Polychlorinated biphenyls -- Toxicology -- Testing.

Statement dc:rights

• Public
• Copyright
• McDonald, Jennifer C.
• Copyright is held by the author, unless otherwise noted. All rights reserved.

Language dc:language

English

Identifier

oclc: 175228558
https://digital.library.unt.edu/ark:/67531/metadc3640/
ark: ark:/67531/metadc3640

OAI identifier oai:identifier

info:ark/67531/metadc3640