Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 49 for “"LD50"”.
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An investigation into the anthelmintic properties of seed extracts from endophyte containing pasture grasses
… For loline producing endophytes, the LD50 for T. colubriformis egg hatching for AR542 and Nil TF were not different from each other (P>0.05) but significantly differed from meadow fescue (P<0.05). Within the rye grass varieties, the LD50 for T. circumcincta egg hatching for AR1 and …
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Novel Virulence Factors in the Pathogenesis of Yersinia pestis Infection, the Causative Agent of Plague
… survival rates at an infectious dose of 40 LD50. Upon sequencing, six of the attenuated mutants carried interruptions in genes encoding hypothetical proteins or proteins with putative functions. In-frame deletion mutation of two of the genes identified from the screen were also found to …
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Synthesis and Pulmonary Toxicity of Several 3-Furyl Ketones: Evidence for the Position of Metabolism by Cytochromes P-450
… to examine the first problem. The 48 h LD50 (ip) in Notre Dame Swiss mice for these analogues was greater than that of perilla ketone (2, 30 (+OR-) 5; 3, 173 (+OR-) 4; 4, 150 (+OR-) 11; 5, 81 (+OR-) 6 (mu)mol/kg). The reduced toxicity of 3, 4, and 5 cannot be explained on the basis of …
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Studies on biological activities of Scottish plants.
… was the methanol extract of Malva moschata (LD50 2.25 X 10-3 mg/mL). The most toxic compound in the BSLA was moschamindole (LD50 = 9.14 X 10-6 muM) followed by hederacine A (LD50 = 1.09 x 10- muM), matairesinol (LD50 = 1.18 x 10-6 muM) when compared to the control podophyllotoxin (LD50 = 6.5 …
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Bacterial Challenge in Lumbricus Terrestris: A Terrestrial Invertebrate Immunotoxicity Model.
… Aeromonous hydrophila, establishing a 10-day LD50. In vitro assays for effects of PCBs on phagocytosis agreed with mammalian studies, demonstrating potent suppression of phagocytosis by the non-coplanar PCB congener 138 and no suppression by the coplanar congener 126. However, when the effects …
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Targeting Traf6 For Cancer Therapeutical Development
… predictive models for the evaluation of the LD50 and bioavailability of our TRAF6 hits, and these models can be used towards other drugs and small molecule therapeutics as well. Datasets of compounds and their corresponding bioavailability and LD50 values were curated based, and QSAR models …
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Germination niche of an emergent invasive grass, Arthraxon hispidus
… required to limit germination to 50% (LD50) in the populations tested surpassed soil salinity found in the contiguous United States and some tidal systems (Frederick, MD = 354; Lincoln, MO = 354; Williamsburg, VA = 298 mM NaCl). While drought adversely affects A. hispidus germination, …
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Transmission of western equine encephalitis virus by Saskatchewan mosquitoes and behavior of the virus in selected laboratory vertebrates in relation to epidemiological studies
… of 108 to 109 intracerebral three-week old mouse LD50 (ic mouse LD50 ) per 0.03 ml of blood. Most infected chicks showed inactivity followed by prostration before death; very few displayed overt clinical signs of neurologic disturbance. In comparative titrations, chicks were more sensitive than …
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Immunotoxicity of Pesticide Mixtures and the Role of Oxidative Stress
… one-third, one-fourth, or one-eight of LD50) of individual pesticides. Exposure to individual pesticides did not alter the thymus/body or spleen/body weight ratios, thymic or splenic cell counts, or CD4/CD8 or CD45/CD90 ratios. However, anti-sRBC plaque forming cell (PFC) counts were …
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Proteasome inhibition in chronic myeloid leukaemia
… from patients with CP CML cells, with an LD50 below concentrations achieved in vivo. We also demonstrate for the first time that CD34+38- CML cells, representing the TKI-insensitive primitive HSC, are similarly susceptible. Bortezomib is associated with inhibition of proteasome activity, …
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DRUG TOXICITY STUDIES BASED ON VIRE2-GFP MOBILITY INSIDE PLANT CELLS
… for toxicity testing for drugs is the use of LD50 and IC50. However, there are multiple disadvantages of such tests, which includes varied results between animals tested and route of drug administration. In this study, we utilised a new testing technology based on the ability to visualise the …
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A bioengineered approach for sustainable crude oil pollution treatment via entrapment, dispersal and removal using Nano-CarboScavenger
… were found to be remarkably un‐inhibitive with LD50: 8 g/L, EC50: 1.28 g/L and IC50: 4 g/L respectively. This far exceeds expected NCS exposure (ENE) of 1x10-5 g/L in bodies of water. Finally, NCS degraded in the presence of human myeloperoxidase (HMPO) and horseradish peroxidase (HRP), …
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Metabolische Veränderungen und Zelltod in neuralen Zellen durch "Advanced Glycation Endproducts"
… verwendeten Protein und vom Zucker. Die LD50 der Modell-AGEs korreliert mit dem AGE-Gehalt und der Radikalproduktion der Präparationen in vitro. Die AGE-Toxizität ist hauptsächlich radikalvermittelt. Oxidativer Stress lässt sich in AGE-behandelten Zellen durch die Bildung intrazellulärer …
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Phytochemical and toxocological studies of some Botswanan plants used in traditional medicine
… fruticosa were found to be the most toxic with LD50 values for the crude extracts of 1.3 -3.4. tg/ml. Phytochemical investigation of the extracts revealed the presence of a variety of secondary metabolites from the plants. A. brevifolia yielded terpenoids, phenolics, phenolic glycosides, a …
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Towards Combined Computational and Experimental Studies on Toxicity of Silver Nanoparticles
… HepG2 cells at a dosage that exceeds 1 ppm and LD50 was observed at 3 ppm. Elevated reactive oxygen species levels were seen upon exposure to AgNPs with the maximum at the LD50 concentration of 3 ppm. Normal protein regulation of HepG2 cells were affected by exposure to AgNPs. TEM images of …
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Investigation into the potential invasiveness of the exotic Narrow-leaved Bittercress, (Cardamine impatiens L.), Brassicaceae
… shade intensity. Plants died very quickly, so LD50 data were used as a relative measure of fitness, and relative growth indices were calculated over time. Other relative measures of fitness included canopy area, leaf area, number of leaves, number of leaves per canopy area, and final plant …
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An investigation into the synergistic action of chemotherapy and photodynamic therapy in resistant skin cancers
… percent decrease in melanoma cell viability (LD50), then to investigate the possible synergism of hypericin activated-photodynamic therapy in reducing (HYP-PDT) melanoma cell viability, when combined with chemotherapy. In addition we wanted to assess the morphology and the clonogenic capacity …
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Approaches towards vaccine development against Neospora caninum
… have been developed. It was found that the LD50 of N. caninum tachyzoites in gerbils was 9.3 x105 tachyzoites per gerbil delivered intra-peritoneally, (i.p) while for C57BL/6 mice the LD50 was 1.5 x107 tachyzoites per mouse delivered i.p. Vertical transmission rates in C57BL/6 mice infected …
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HUMAN DPP4/CD26 TRANSGENIC MICE AS SURROGATE MODELS FOR MERS
… studies identified the 50% lethal dose (LD50) and the 50% infectious dose (ID50) of MERS-CoV to be ~5 and 0.4 TCID50 of MERS-CoV, respectively. This Tg mouse model has been used successfully as a robust preclinical model for testing the efficacy of medical countermeasures for MERS.
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Bioremediation of heavy metal polluted water using immobilized freshwater green microalga, botryococcus sp.
… for the Chemical oxygen demand (COD). In the LD50 experiment, immobilized biomass harvested from the bioremoval study experiment were used on fishes for toxicity testing. A total of 100% mortality was recorded in the positive control after 24 hours whereas, 3% mortality was observed in …
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