Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 31 for “"Immunotoxicity"”.
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QSAR study of immunotoxicity in antibiotics.
Since their inception the B-Iactam antibiotics have become one of the most important classes of phannaceutical agents, both therapeutically and economically, in modern day usage for the treatment of a wide spectrum of bacterial infections. However, due to the versatility of bacteria many previously …
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Evaluating Immunotoxicity of Quaternary Ammonium Compounds
… but have not been evaluated for developmental immunotoxicity. We assessed immunotoxicity in-vitro with J774A.1 murine macrophage cell line by analyzing cytokine production and phagocytosis; and evaluated developmental immunotoxicity in CD-1 mice by analyzing antibody production. Additionally, …
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Bacterial Challenge in Lumbricus Terrestris: A Terrestrial Invertebrate Immunotoxicity Model.
A bacterial challenge assay was developed utilizing the earthworm, Lumbricus terrestris, in order to assess potential immunotoxic effects from exposure to specific polychlorinated biphenyl congeners. Earthworms were inoculated with Aeromonous hydrophila, establishing a 10-day LD50. In vitro assays …
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Pesticide Mixtures Induce Immunotoxicity: Potentiation of Apoptosis and Oxidative Stress
The three insecticides of interest were lindane (an organochlorine), malathion (an organophosphate) and piperonyl butoxide (PBO; a synergist). Based on minimum cytotoxicity (> LC25), the following concentrations were chosen for the pesticide mixture studies: 70μM lindane (Lind), 50μM malathion …
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Immunotoxicity of Pesticide Mixtures and the Role of Oxidative Stress
The immunotoxic effects of multiple pesticide exposure were evaluated. C57BL/6 mouse thymocytes were exposed to lindane, malathion, and permethrin, either separately or in mixtures of two pesticides, in concentrations ranging from 37.5 uM to 1mM. These exposures caused both apoptotic and necrotic …
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Identification of Metabolic Markers as Potential Early Predictors of PFAS- Induced Immunotoxicity
… to understand potential PFAS-mediated B cell immunotoxicity mechanisms. We examined five PFAS compounds: PFOA and four short-chain PFAS, perfluoro-2-methoxyacetic acid (PFMOAA), 3,5,7,9-butaoxadecanoic acid (PFO4DA), perfluoro (3,5-dioxahexanoic acid; PFO2HxA), and …
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Apoptosis as a Mechanism of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)-Induced Immunotoxicity
… Fas and Fas ligand play a role in TCDD-mediated immunotoxicity. Administration of a single dose of TCDD at 0.1, 1, 5 or 50 mg/kg body weight intraperitoneally into C57BL/6 +/+ mice caused a significant dose-dependent decrease in the thymic cellularity; whereas, in the C57BL/6 lpr/lpr (lpr) …
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TOWARD SUSTAINABLE CHEMICAL SUBSTANCES: DEVELOPMENT OF NOVEL APPROACH METHODOLOGIES TO STUDY IMMUNOTOXICITY OF PFAS
Il sistema immunitario, essenziale per la protezione contro i patogeni, la regolazione dell'infiammazione e il mantenimento dell'omeostasi tissutale, è altamente vulnerabile ai contaminanti ambientali. Tra questi, le sostanze per- e polifluoroalchiliche (PFAS) sono una vasta classe di sostanze …
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Immunotoxicity of Dermal Permethrin and Cis-Urocanic Acid: Effects of Chemical Mixtures in Environmental Health
The present study examined adverse effects of sunlight exposure (mimicked by intradermal cis-urocanic acid, cUCA) on local and systemic immune responses, with or without co-exposure to the immunotoxic insecticide permethrin. A single exposure to cUCA caused diminished splenic macrophage …
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Mechanism of TCDD-Induced Immunotoxicity: The Role of Cell Activation in the Generation of Toxicity
2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin is well known for its immunotoxic effects on the thymus, as well as on B and T lymphocyte functions. Previous studies suggested that TCDD exerted immunotoxic effects only on cells differentiating in response to antigenic challenge. To this date, no work has …
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Harnessing In Silico platform for Vaccine Discovery, Disease Modeling, and Immunotoxicity Prediction in Pandemic and Emergency Scenarios
Il mondo moderno affronta sfide senza precedenti derivanti da pandemie ed emergenze, richiedendo soluzioni innovative per una gestione efficace. Questa tesi affronta problematiche di salute globale utilizzando strumenti computazionali avanzati per la scoperta di vaccini, la modellazione delle …
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Immunotoxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and Diethylstilbestrol (DES) in the Fetal Mouse Thymus and Liver
Diethylstilbestrol (DES) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) have been identified as immunotoxicants causing thymic atrophy, thymocyte hypocellularity, phenotypic changes detected by CD4 and CD8 surface antigens, and progenitor T-cell targeting in the fetal mouse. We hypothesized that …
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Use of the Immune System to Investigate the Toxicity Induced by Environmental Pollutants in Fish, Amphibian, and Mammalian Species
… with 1,3-Bis (chloroethyl)-1-nitrosourea (BCNU). Immunotoxicity of the tilapian immune system was detectable using mitogen-induced proliferation assay and cell-mediated toxicity assay. Fish from various streams of the Roanoke River were tested for immunotoxicity and parasitic infection. Fish from …
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Immunotoxicity of TCDD: role of Fas expression and MHC phenotype on TCDD-mediated thymic atrophy and decrease in peripheral T cell responsiveness
… (MHC)-encoded molecules, however, its role in immunotoxicity is not clear. In this study, we investigated the role of Fas (CD95), an important molecule involved in the induction of apoptosis, on TCDD-mediated immunotoxicity using mice bearing homozygous lpr mutation which leads to failure of …
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The Development and Application of a Hemolytic Plaque Forming Cell Assay (PFC) and a Cytotoxic T-Lymphocyte Assay (CTL) in Tilapia (Oreochromis niloticus) for Immunotoxicity Risk Assessment of Environmental Contaminants
… an alternative experimental model to mammals for immunotoxicity risk assessment is currently being proposed. As such, the National Toxicology Program's (NTP) standard battery of rodent immunotoxicity assays is being developed for use in this fish species. Included in the testing series are the …
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Immune Function Determination in Mice Dermally Exposed to Permethrin
… showing limited but significant systemic immunotoxicity following low-level topical exposure to the pyrethroid insecticide, permethrin (formerly not considered an immunotoxicant). Permethrin was applied to the shaved dorsal interscapular region of C57Bl/6N mice at doses of 0.5, 1.5, or 5.0 …
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Breast Cancer Fund: Power Mapping for Policy Change
… environment that are linked to breast cancer, immunotoxicity, and reproductive and developmental issues. BCF accomplishes these goals through public awareness and pushing for policy change. In April 2015, Senators Diane Feinstein and Susan Collins introduced the Personal Care Products Safety …
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Cationic Polymers and Polymeric Micelles as Plasmid DNA and CRISPR-Cas9 Ribonucleoprotein Delivery Vehicles
… low production cost, chemical flexibility, low immunotoxicity, and the ability to encapsulate biomacromolecules. However, the precise control of polymeric vehicle properties by structure-tuning is a general challenge. Hence, the fundamental understanding of polymeric vehicle’s structure-property …
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Immunotoxicological Evaluation Of Critical Windows Of Development Following Exposure to 1,2:5,6 Dibenzanthracene in B6C3F1 Mice
… mice is the most vulnerable to DBA-induced immunotoxicity with a 200-fold enhancement in immunosuppression of the PFC response as compared to adult mice. These studies provide insight into how environmental contaminants, such as DBA, may impact children's health.
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