Biosynthetic characterisation of secondary metabolites from stromatolite cyanobacteria Symploca sp. 1013

Cyanobacteria are known to produce secondary metabolites that exhibit a wide range of chemical activities. Many of these compounds are toxins, however, an increasing amount of metabolites with potential therapeutic bioactivities are also being discovered. The majority of these metabolites are formed due to the presence of polyketide synthase (PKS) or non-ribosomal peptide synthetise (NRPS). Bioactivities in areas such as antibacterial, antifungal and anticancer have been implicated in many of these metabolites. In the present study, various marine cyanobacterial isolates from from stromatolites in Shark Bay, Western Australia, were screened for the presence of PKS and NRPS. The presence of both secondary metabolite pathways were seen in the Symploca sp. 1013 as well as 5 stromatolite samples with PKS and/or NRPS genes. Symploca sp. 1013 was further investigated through genetic, biochemical and pharmacological approaches. Findings from this study support the idea that cyanobacteria do have the potential to produce secondary metabolites. Unfortunately no bioactivity was determined through the strains and cell lines used in the bioassays. Furthermore, this is the first study to investigate the genetic potential of Symploca sp. 1013 from Shark Bay as well as screen the other stromatolite cyanobacterial isolates.

Grantor dc:publisher

UNSW, Sydney

Year dc:date

2011

Author dc:creator

• Pradhan, Neha Kiran

• Secondary Metabolites
• Cyanobacteria
• Symploca
• NRPS
• PKS
• Natural products

Statement dc:rights

• open access
• CC BY-NC-ND 3.0
• free_to_read

Licence

• https://purl.org/coar/access_right/c_abf2
• https://creativecommons.org/licenses/by-nc-nd/3.0/au/

Language dc:language

EN

Identifier

https://doi.org/10.26190/unsworks/23834

OAI identifier oai:identifier

oai:unsworks.library.unsw.edu.au:1959.4/51278