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Showing 1 to 20 of 36 for “"NRPS"”.

  1. Comparative and Functional Genomic Analysis of <i>Streptococcus Equi</i> and <i>Streptococcus Zooepidemicus</i> : Identifying Novel Vaccine Targets

    Heather, ZoeThe Open University2009

    … nonribosomal peptide synthetase (NRPS) system. The NRPS shares similarity with the yersiniabactin system found in the high pathogenicity island of <i>Yersinia pestis</i> and is the first of its kind to be identified in streptococci. As this genetic feature is absent from the <i>S. …

    the-open-u Repository record

  2. Reengineering and Discovery of Nonribosomal Peptide Synthetases

    Evans, Bradley S.University of Illinois at Urbana-Champaign2011

    … assembled on nonribosomal peptide synthetase (NRPS) assembly lines covalently tethered to the synthetases throughout biosynthesis. Mass spectrometry is an especially well suited tool for analyzing both the products of NRPS pathways and the machinery that produces them. A review of NRPS …

    uiuc Repository record

  3. Biosynthetic characterisation of secondary metabolites from stromatolite cyanobacteria Symploca sp. 1013

    Pradhan, Neha KiranUNSW, Sydney2011

    … (PKS) or non-ribosomal peptide synthetise (NRPS). Bioactivities in areas such as antibacterial, antifungal and anticancer have been implicated in many of these metabolites. In the present study, various marine cyanobacterial isolates from from stromatolites in Shark Bay, Western Australia, …

    unsw Repository record

  4. Studies of new natural products and their biosynthesis spearheaded by high-resolution mass spectrometry

    Bumpus, Stefanie B.University of Illinois at Urbana-Champaign2010

    … by non-ribosomal peptide synthetases (NRPSs) and polyketide synthases (PKSs). In NRPS and PKS biosynthesis, monomer units are incorporated into a growing natural product chain in an assembly line fashion using a covalent thiotemplate mechanism. Because the growing natural product is …

    uiuc Repository record

  5. Identification and preliminary characterization of the 2,5-diphenyloxazole biosynthetic pathway in streptomyces polyantibioticus SPRT

    Kemp, Ian KyleDepartment of Molecular and Cell Biology2015

    … whereby a non-ribosomal peptide synthetase (NRPS) condenses a molecule of benzoic acid with 3-hydroxyphenylalanine. The dipeptide is converted to a diphenyloxazole derivative by heterocyclization and a final decarboxylation step leads to DPO. To determine whether the hypothesis pertaining to …

    cape-town Repository record

  6. Investigation of a novel iron-uptake system and other genomic features in mecC Staphylococcus aureus

    Raisen, ClaireUniversity of Cambridge2019

    … non-ribosomal peptide synthetase (NRPS), directly downstream of the SCCmec insertion site in mecC S. aureus isolates. A homologous region was identified in Streptococcus equi 4047 (S. equi) which encodes a NRPS termed ‘equibactin’ that is involved in iron acquisition. I have …

    cambridge Repository record

  7. Analysis of the diverse antibacterial strategies used by <i>Serratia marcescens</i> Db10

    Gerc, AmyUniversity of Dundee2014

    … peptide synthetases (NRPS) and polyketide synthases (PKS) are widespread in bacteria and fungi and are responsible for the biosynthesis of many metabolites with medically relevant properties, including antibiotics. The activity of NRPS and PKS enzymes is dependent on …

    dundee Repository record

  8. Insights into the Synthesis, Mechanism of Action, and Biosynthesis of a Novel Lipodepsipeptide Antibiotic, WAP-8294A2

    Blackledge, Meghan Scobee2011

    … We successfully identified the WAP-8294A NRPS biosynthetic gene cluster in L. staphylocidin. It is composed of two large open reading frames (ORFs) that encode NRPS machinery made up of 44 domains organized into 12 modules. The organization of the gene cluster argues for a co-linear …

    duke Repository record

  9. Characterizing and Engineering Thioesterases as Biocatalysts for Macrocyclization

    Brazeau-Henrie, JordanUniversité d'Ottawa / University of Ottawa2024

    … of two non-ribosomal peptide synthetase (NRPS) TE domains and their use as biocatalysts for the chemoenzymatic synthesis of two cyclic depsipeptide NP. Unlike other characterized NRPS TEs, these two demonstrated the ability to catalyze macrolactonization with minimal competing hydrolysis …

    ottawa-retro Repository record

  10. A genomics-led approach to deciphering heterocyclic natural product biosynthesis

    Chan, Karen Hoi-LamUniversity of Cambridge2019

    … synthase-nonribosomal peptide synthetase (PKS-NRPS) pathway in Streptomyces sp. KO-7888 and Streptomyces sp. OM-5714. The phthoxazolin pathway was used as a model to study 5-oxazole and primary amide formation in PKS-NRPS pathways. An unusually large gene cluster for phthoxazolin biosynthesis …

    cambridge Repository record

  11. Investigation of the antibacterial activity and the biosynthesis gene cluster of the peptide antibiotic feglymycin

    Rausch, Saskia2012

    … um ein nicht-ribosomal synthetisiertes Peptid (NRPS) handelt dessen Biosynthese der Biosynthese der Glycopeptidantibiotika der Vancomycin-Gruppe von Antibiotika ähnelt. Zudem konnten im Streptomyces sp. DSM 11171 Genom weitere NRPS und Polyketidsynthase (PKS) Gencluster identifiziert und …

    tu-berlin Repository record

  12. Identificación y caracterización de agrupaciones de genes de biosíntesis para péptidos no ribosomales en Streptomyces sp. CS113

    García Gutiérrez, Coral2022

    … Sintetasas de Péptidos No Ribosomales (NRPS) o Policétidos Sintasas (PKS) respectivamente.

    oviedo Repository record

  13. Studies on the biosynthesis of oudenone and verucopeptin

    Yang, Xianshu2000

    … non-ribosomal peptide synthetase enzymes (NRPS). Based on the chemical structure of verucopeptin, the enzymatic motifs identified are consistent with those expected to be associated with its biosynthesis. A gene disruption experiment was performed with A. verrucosospora in order to …

    concordia Repository record

  14. Catalytic C-H oxidation reactions for the synthesis and diversification of hydroxyamino acid motifs

    Osberger, Thomas JosephUniversity of Illinois at Urbana-Champaign2016

    … products of nonribosomal peptide synthetase (NRPS) origin posses complex topologies and diverse functional group arrays that lead to varied and impressive therapeutic potential. The structural diversity achieved among these natural products is due in large part to a biosynthetic strategy that …

    uiuc Repository record

  15. Stammdesign in B. licheniformis

    Rachinger, Michael2012

    … reduzierten Satz an potentiellen Prophagen. Drei NRPS-Gencluster mit Ähnlichkeiten zu Genen aus der Fengycin, Bacitracin und Lichenysin-Biosynthese konnten identifiziert werden.

    goettingen Repository record

  16. Discovering novel natural products from bioactive plants and bacteria

    Luo, YunziUniversity of Illinois at Urbana-Champaign2012

    … from Streptomyces griseus, containing a PKS/NRPS hybrid gene, was chosen as a model system. To decipher this cluster, I have been attempting to develop a new strategy based on our recently developed “DNA assembler” method. By using this approach, the gene cluster was modified by adding …

    uiuc Repository record

  17. Magneto-optical oxide thin films and integrated nonreciprocal photonic devices

    Bi, Lei, Ph.D. Massachusetts Institute of TechnologyMassachusetts Institute of Technology2011

    … demonstrated. Strong nonreciprocal phase shift (NRPS) has been demonstrated in chalcogenide glass/magnetic oxide and magnetic oxide/silicon strip-loaded waveguides by numerical simulations. A nonreciprocal optical racetrack resonator based on polycrystalline garnet/silicon strip-loaded waveguides …

    mit Repository record

  18. A functional genomics approach: Characterisation of two Non-ribosomal peptide synthetase genes, and investigation of an adaptive response towards alkylating DNA damage in Aspergillus fumigatus.

    O'Hanlon, KarenNational University of Ireland Maynooth2010

    … this work further highlights the importance that NRPS plays in this serious human pathogen, and uncovered some interesting features such as possible secondary metabolite cluster cross-talk and NRP synthetase redundancy, themes which are beginning to emerge in the literature.

    maynooth Repository record

  19. Antimicrobial activities and diversity of sponge derived microbes

    Flemer, BurkhardtUniversity College Cork2013

    … secondary metabolite genes. At least 5 different NRPS genes, with a sequence similarity as low as 50 % to known genes, were identified highlighting the likelihood that this isolate may be capable of producing novel secondary metabolites. A Micromonospora sp. was isolated from a Haliclona simulans …

    cork Repository record

  20. Characterisation of microbial Mat communities in meltwater ponds of the McMurdo ice shelf, Antarctica

    Jungblut, Anne DorotheeUNSW, Sydney2007

    … However non-ribosomal peptide synthetases (NRPS) and polyketide synthases (PKS) genes were identified which could be the genetic basis for novel bioactives. The use of a multi-disciplinary approach synthesis and subsequent results significantly increased our understanding of the diversity …

    unsw Repository record

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