University of New Mexico
Development of Soft-Matter Delivery Systems: Coupling pH Responsive Polymers to Porous Silica Particles
Abstract
dc:description.abstract<p>This work investigates polymeric coating of evaporated induced self-assembly (EISA) mesoprous silica nanoparticles for potential use in controlled drug release and therapeutics. As demonstrated here, lipid bilayer coatings can be easily replaced with different polymer analogs allowing for dynamic response to environmental stimuli. In addition to coupling commercially available diblock polymers we synthesized and characterized a unique dual hydrophilic pH responsive diblock copolymer, PEO-PAA. This hybrid polymeric-nanoparticle system drastically improves targeting and release capabilities through the modular ability to couple multiple different polymers. Furthermore, this work is supported by an improved method to form and study giant polymer vesicles (pGVs)</p>
Degree
thesis:*- Name thesis:degree_name
- Biomedical Engineering
- Level thesis:degree_level
- Thesis
- Discipline thesis:degree_discipline
- Biomedical Engineering
- Year dc:date.available
- 2015
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Gomez, Andrew
- Contributors dc:contributor
-
- C. Jeffrey Brinker
- Eric C. Carnes
- Carlee E. Ashley
Subjects
dc:subject × 8Rights
- Language dc:language
- English
Identifiers
dc:identifier.*- Identifier
- https://digitalrepository.unm.edu/bme_etds/3
- OAI identifier oai:identifier
- oai:digitalrepository.unm.edu:bme_etds-1002