Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"protocell"”.
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Lateral Transfer of DNA in Protocell-like Synthetic Cells
… horizontal movement of genetic material among protocells. Additionally, this work highlights key experimental challenges in modeling prebiotic genetic exchange, while also contributing to the development of synthetic biological systems that emulate early evolutionary processes.
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Design and Characterisation of a Novel Artificial Life System Incorporating Hierarchical Selection
… to exist within externally provided containers - protocells. This research is focused on the period of time surrounding the conjectured first Major Transition - from individual replicating molecules to populations of molecules existing within cells. Protocells can be thought of as simplified …
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The behaviour of fatty acid vesicles in prebiotically plausible environments
… analogue to the cell -- also known as the protocell. To flourish, they should have performed key functions enabling growth, and ensuring their survival and propagation. While researchers study a variety of model protocell systems, the study of model protocells assembled from fatty acid …
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Engineering artificial cell membranes by Ting F. Zhu.
… origin of cellular life is how primitive cells (protocells) lacking complex biological machinery could grow and divide. To address this question, we first developed an effective method for preparing large monodisperse (uniform-sized) vesicles through a combination of extrusion and large-pore …
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Development of novel bio/nano interfaces for materials science and biomedical applications
… silica nanoparticle-supported lipid bilayer (protocell') for targeted delivery applications. Protocells combine enhanced specificity, stability, and cargo capacity when compared to similarly-sized liposomes. They can, additionally encapsulate and deliver multicomponent cargos. Due to their …
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Chemically driven soft bioinspired systems and the variational formulation of physics-informed neural networks
… the gel diffusiophoresis. Second, we investigate protocells — giant unilamellar lipid vesicles that preceded the first unicellular organisms. We analyze the spontaneous formation of subcompartments within these protocells. Using a continuum elastohydrodynamic theory, we demonstrate how attractive …
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Development of Soft-Matter Delivery Systems: Coupling pH Responsive Polymers to Porous Silica Particles
<p>This work investigates polymeric coating of evaporated induced self-assembly (EISA) mesoprous silica nanoparticles for potential use in controlled drug release and therapeutics. As demonstrated here, lipid bilayer coatings can be easily replaced with different polymer analogs allowing for …