Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"MSNs"”.
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SYNTHESIS, SURFACE MODIFICATION, AND CHARACTERIZATION OF BIOCOMPATIBLE MULTIFUNCTIONAL NANOPARTICLES
… dyes loaded in mesoporous silica nanoparticles (MSNs). Here, a rhodamine derivative, TRITC-dextran (tetramethyl rhodamine isothiocyanate conjugated dextran), the hydrophilic dye, was loaded in MSNs through the water-in-oil microemulsion method, while, the hydrophobie dye, FITC (fluorescein …
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Exploring central and enteric nervous system vulnerability in Huntington’s Disease: hints from a knock-in animal model
… within the brain. Medium-sized spiny neurons (MSNs), the main neuronal components of the striatum, are selectively affected by HD, and they can be further categorized by their surface expression of Dopamine receptors 1 (D1R) and 2 (D2R). These two populations exhibit distinct vulnerabilities, …
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Morphogenetic Principles of Brain Organisation in Health and Disease
… the resulting morphometric similarity networks (MSNs), with an emphasis on reproducibility. Chapter 3 highlights the generalisability of MSNs to the macaque monkey, linking MSNs to ex vivo tract tracing experiments and presenting new tools for processing non-human imaging data; as well as …
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PREPARATION AND EVALUATION OF MESOPOROUS SILICA NANOPARTICLES FOR PLATINUM-ACRIDINE ANTICANCER DRUG DELIVERY
Mesoporous silica nanoparticles (MSNs) have a wide range of applications in the basic and biomedical sciences. Because of their unique pore structures and physicochemical properties, MSNs have recently attracted major attention as an inert carrier material in oncology drug formulations. In this …
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Morphological characterization of medium spiny neuron development in vitro
Medium Spiny Neurons (MSNs) are the primary cell type of the striatum, a structure critically involved in motivation, memory, and movement. MSN structure and function are altered in Parkinson’s and Huntington’s disease as well as following repeated exposure to drugs of abuse. One site on the MSN …
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Modelling Huntington’s Disease Using Direct Cell Reprogramming
… degeneration of striatal medium spiny neurons (MSNs) is limited. This may be due to the challenge of generating a representative model of HD. Cell reprogramming is a revolutionary technology that can generate live, human neurons in vitro from the somatic cells of individuals with HD. Our …
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Hybrid Brain-Tissue Based Model to Study the Role of Infiltrating Monocytes in Late Stage Huntington's Disease
… by selective loss of medium spiny neurons (MSNs) in the striatum and cortical neurons in the cortex. It is caused by an expansion of CAG repeats in the exon-1 of IT-15 gene, which results in a mutated polyglutamine domain in the huntingtin protein (HTT) (Collaborative, 1993). The mutation …
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Cell-Type Specific Translational Profiling in Huntington's Disease Mouse Models
<p>Medium spiny neurons (MSNs) are among the most vulnerable cell populations in Huntington's Disease (HD). Within this population, striatopallidal MSNs are more vulnerable than striatonigral MSNs, which may explain the typical progression in HD of chorea to hypokinesis. The biological basis for …
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Genetic Dissection of Neural Circuits Underlying Value Based Decision Making
… and indirect pathway medium spiny neurons (MSNs), showed partially overlapping but distinct behavioral effects. Inactivation of direct pathway MSNs showed the stronger effect on learning while inactivation of indirect pathway MSNs also showed the effect. In contrast, only inactivation of …
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Inorganic nanoparticles for applications in biomedical sciences
… certain extent. Mesoporous silica nanomaterials (MSNs) are widely studied for drug delivery applications; Mobile Crystalline Material-41 (MCM-41), a type of MSN, that has a mesoporous structure with pores forming channels in a hexagonal fashion. We used MCM-41 mesoporous silica nanoparticles for …
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Ethanol priming and its effects on consumption and accumbal plasticity
… receptor (D2) expressing medium spiny neurons (MSNs) that precipitate different intracellular cascades and actions upon the reward circuitry. Alterations in the expression N-methyl-D-aspartate receptor (NMDAR)-dependent long-term depression (LTD) in the D1 MSNs of the NAc shell are seen …
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Effect of Mesoporous Silica-Loaded Anticancer Drugs on 3D vs 2D Models of Colon Cancer Cells
… loaded onto mesoporous silica nanoparticles (MSNs) and tested on 3D spheroids and 2D monolayer cells of the HCT116 colon cancer cell line. Due to its poor water solubility, DMU121, a synthesised chalcone with potential anticancer properties, was encapsulated onto MSNs. MSNs, biocompatible …
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Dopamine-dependent Transcriptional Dynamics in Striatal Physiology and Cocaine Reward
… responses of NAc medium spiny neurons (MSNs) following acute cocaine experience. Acute cocaine exposure produced rapid but prolonged increases in neuronal activity of a subpopulation of neurons in the NAc. Using a real-time place conditioning behavioral assay in combination with viral …
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Nucleus accumbens GABAA receptor-mediated inhibitory transmission: Relevance to early life stress and addiction
… shown for accumbal medium spiny neurons (MSNs) that α2-subunit containing GABAA receptors (α2-GABAARs), mediate phasic inhibition and that their genetic inactivation (α2-/-) abolishes behavioural sensitisation to cocaine. Recently, linkage association studies in humans revealed a genetic …
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RESTORING CONNECTIVITY IN PARTITIONED WIRELESS SENSOR NETWORKS
… Networks (WSNs) and Mobile Sensor Networks (MSNs) can be prone to failures due to limited resources and/or the harsh environments where they are deployed. The network may be subject to partitioning if such failures are experienced by the cut-vertex nodes in the system. In case of …
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The Measure and Meaning of Structural Similarity in the Brain
… approach of morphometric similarity networks (MSNs) on N>11,000 scans spanning three human datasets and one macaque dataset, MIND networks were more reliable, more consistent with cortical cytoarchitectonics and symmetry, and more correlated with tract-tracing measures of axonal connectivity. …
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Investigating three-dimensional (3D) gelatin methacryloyl (GelMA) hydrogel as a potential scaffold for cell transplantation in Huntington's disease
… survival and differentiation of hiLGEPs-derived MSNs for CRT. First, the study optimised the flow-focusing microfluidic systems to generate GelMA hydrogel microspheres with a diameter of 100-150 µm. However, none of these systems showed a reliable performance in producing the monodispersed …
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Anatomical and Physiological Characterization of Striatal Activation of the Cerebral Cortex
… by direct pathway medium spiny neurons (dMSNs) expressing D1 type dopamine (DA) receptors (D1Rs) and indirect pathway MSNs (iMSNs) expressing D2 DA receptors (D2Rs). Loss of DA results in the imbalance between the activities of dMSNs and iMSNs in Parkinson’s disease (PD), leading to …
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Nanotechnology-based strategies for periodontitis: nanoparticles as drug delivery systems and antimicrobial agents against biofilm formation
… πυριτίας (mesoporous silica nanoparticles - MSNs) διαθέτουν υψηλή ικανότητα φόρτωσης φαρμάκου και ρυθμιζόμενους ρυθμούς απελευθέρωσης, ενώ στα υβριδικά και στα συνθετικά συστήματα νανοσωματιδίων-υδρογέλης εκμεταλλεύεται η πολυλειτουργικότητα τους για να βελτιωθεί η διείσδυση τους στο …
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Pharmacological inhibition of CK2: the effect of an FDA designated orphan drug on pathology, neuroinflammation, and glial phenotypes in Huntington’s disease
… decreased the number of medium spiny neurons (MSNs) and allowed increased infiltration of mHtt aggregates into white matter fascicles. Removal of GFAP+ astrocytes also increased the number of white matter fascicles in the DMS. Overall, these results support a neuroprotective role for GFAP+ …
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