Biodegradable, Liquid-Filled, Spherical Capsules With Pre-Determined Burst Times

A biodegradable poly(lactic acid-co-glycolic acid) (PLGA) capsule is presented in a spherical geometry, which exploits the principle of osmosis as an internal program to achieve a delayed-burst release of its load. The capsule burst lag-time is accurately predicted by modeling the rate of water uptake by the capsule core as a function of the capsule shell thickness, radius of the capsule, core osmotic pressure and the membrane tensile strength. Elastoplastic and failure characterization of PLGA was conducted as a function of hydration under uniaxial and biaxial stretch and by a novel “beach ball” inflation technique. The presence of small amounts of moisture leads to a decrease in yield stress and a decrease in elongation at break. The above presentation suggests reproducible preparation and evaluation of spherical rupturable osmotic capsules.

Author dc:creator

• Harish Jain, Krutika

• Burst-type
• Chronopharmaceutics
• Elasto-plastic
• Mathematical Model
• Osmotic pumps
• PLGA

Language dc:language.iso

en

Handle dc:identifier.uri

http://hdl.handle.net/11299/190596

OAI identifier oai:identifier

oai:conservancy.umn.edu:11299/190596